Sat2 spermidine/spermine N1-acetyltransferase family member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sat2provided by RGD
Official Full Name: spermidine/spermine N1-acetyltransferase family member 2provided by RGD
Primary source: RGD:1307869
See related: EnsemblRapid:ENSRNOG00000011714 AllianceGenome:RGD:1307869
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable diamine N-acetyltransferase activity and identical protein binding activity. Predicted to be involved in polyamine metabolic process. Orthologous to human SAT2 (spermidine/spermine N1-acetyltransferase family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 236.4), Heart (RPKM 95.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54839531..54841651)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54340756..54343507)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56227703..56229796)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ulinastatin can effectively reduce the cardiac function damage caused by cardiopulmonary resuscitation, which could be related with the increased SSAT2 and decreased AQP4.
Title: The regulation effect of ulinastatin on the expression of SSAT2 and AQP4 in myocardial tissue of rats after cardiopulmonary resuscitation.
Our results indicate that both isoforms are expressed in MNTB principal neurons, and demonstrate that functional system A transporters are present in the plasma membrane of neurons.
Title: Functional expression of two system A glutamine transporter isoforms in rat auditory brainstem neurons.
SAT2 maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate
Title: System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate.
pronounced expression of SN1 and SAT2 in B-cells and A-cells, respectively, was shown suggesting pronounced expression of SN1 and SAT2 in B-cells and A-cells, respectively.
Title: Complementary expression of SN1 and SAT2 in the islets of Langerhans suggests concerted action of glutamine transport in the regulation of insulin secretion.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
NOT enables diamine N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables diamine N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in nor-spermidine metabolic process	ISO Inferred from Sequence Orthology more info
NOT involved_in polyamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in putrescine acetylation	ISO Inferred from Sequence Orthology more info
NOT involved_in spermidine acetylation	ISO Inferred from Sequence Orthology more info
involved_in spermidine acetylation	ISO Inferred from Sequence Orthology more info
involved_in spermine acetylation	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thialysine N-epsilon-acetyltransferase

Names: diamine N-acetyltransferase 2; diamine acetyltransferase 2; spermidine/spermine N1-acetyl transferase 2

NP_001101748.1

EC 2.3.1.57

XP_006246805.2

EC 2.3.1.57

XP_006246806.1

EC 2.3.1.57

XP_008766059.2

EC 2.3.1.57

XP_038942244.1

EC 2.3.1.57

XP_038942245.1

EC 2.3.1.57

XP_038942246.1

EC 2.3.1.57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108278.1 → NP_001101748.1 thialysine N-epsilon-acetyltransferase

See identical proteins and their annotated locations for NP_001101748.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HFS3

Conserved Domains (1) summary

pfam00583
Location:71 → 144

Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

54839531..54841651

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086317.2 → XP_038942245.1 thialysine N-epsilon-acetyltransferase isoform X1

UniProtKB/TrEMBL

A6HFS2

Conserved Domains (1) summary

pfam00583
Location:90 → 163

Acetyltransf_1; Acetyltransferase (GNAT) family
XM_006246743.4 → XP_006246805.2 thialysine N-epsilon-acetyltransferase isoform X2

UniProtKB/TrEMBL

A6HFS3

Conserved Domains (1) summary

pfam00583
Location:71 → 144

Acetyltransf_1; Acetyltransferase (GNAT) family
XM_008767837.4 → XP_008766059.2 thialysine N-epsilon-acetyltransferase isoform X3

Conserved Domains (1) summary

pfam00583
Location:19 → 116

Acetyltransf_1; Acetyltransferase (GNAT) family
XM_039086316.2 → XP_038942244.1 thialysine N-epsilon-acetyltransferase isoform X1

UniProtKB/TrEMBL

A6HFS2

Conserved Domains (1) summary

pfam00583
Location:90 → 163

Acetyltransf_1; Acetyltransferase (GNAT) family
XM_039086318.2 → XP_038942246.1 thialysine N-epsilon-acetyltransferase isoform X3

Conserved Domains (1) summary

pfam00583
Location:19 → 116

Acetyltransf_1; Acetyltransferase (GNAT) family
XM_006246744.5 → XP_006246806.1 thialysine N-epsilon-acetyltransferase isoform X2

See identical proteins and their annotated locations for XP_006246806.1

UniProtKB/TrEMBL

A6HFS3

Related

ENSRNOP00000107968.1, ENSRNOT00000161062.1

Conserved Domains (1) summary

pfam00583
Location:71 → 144

Acetyltransf_1; Acetyltransferase (GNAT) family