Eif6 eukaryotic translation initiation factor 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif6provided by RGD
Official Full Name: eukaryotic translation initiation factor 6provided by RGD
Primary source: RGD:1305373
See related: EnsemblRapid:ENSRNOG00000049497 AllianceGenome:RGD:1305373
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: eIF-6; Itgb4bp
Summary: Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in several processes, including regulation of megakaryocyte differentiation; regulation of primary metabolic process; and ribosome biogenesis. Predicted to be located in cytoplasm; lamin filament; and nucleoplasm. Predicted to be active in cytosol; nucleus; and synapse. Orthologous to human EIF6 (eukaryotic translation initiation factor 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 471.1), Thymus (RPKM 342.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (164785162..164791410, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (144325038..144331396, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (151356867..151363201, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eukaryotic translation initiation factor 6-mediated ribosome biogenesis promotes synovial aggression and inflammation by increasing the translation of SP1 in rheumatoid arthritis.
Title: Eukaryotic translation initiation factor 6-mediated ribosome biogenesis promotes synovial aggression and inflammation by increasing the translation of SP1 in rheumatoid arthritis.
Thus, this work uncovers a new translational cardiac regulator independent by other well-known factors such as mTOR signalling or eIF2beta.
Title: Upregulation of eIF6 inhibits cardiac hypertrophy induced by phenylephrine.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ribosomal large subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal large subunit binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in assembly of large subunit precursor of preribosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in cytosolic ribosome assembly	IEA Inferred from Electronic Annotation more info
involved_in cytosolic ribosome assembly	ISO Inferred from Sequence Orthology more info
involved_in maturation of 5.8S rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of LSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in miRNA-mediated gene silencing by inhibition of translation	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by inhibition of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in miRNA-mediated post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated post-transcriptional gene silencing	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of megakaryocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosomal large subunit biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosomal subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal subunit export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in lamin filament	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 6

Names: integrin beta 4 binding protein

NP_001032429.1

EC 3.6.5.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037352.1 → NP_001032429.1 eukaryotic translation initiation factor 6

See identical proteins and their annotated locations for NP_001032429.1

Status: PROVISIONAL

Source sequence(s)

BC105764

UniProtKB/Swiss-Prot

Q3KRD8

UniProtKB/TrEMBL

A0A8I5ZQX8

Related

ENSRNOP00000080957.1, ENSRNOT00000116245.2

Conserved Domains (1) summary

PTZ00136
Location:1 → 244

PTZ00136; eukaryotic translation initiation factor 6-like protein; Provisional