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    Gp9 glycoprotein IX (platelet) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502858, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gp9provided by RGD
    Official Full Name
    glycoprotein IX (platelet)provided by RGD
    Primary source
    RGD:1561601
    See related
    EnsemblRapid:ENSRNOG00000010015 AllianceGenome:RGD:1561601
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including blood coagulation, intrinsic pathway; megakaryocyte development; and positive regulation of platelet activation. Predicted to be part of glycoprotein Ib-IX-V complex. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome. Orthologous to human GP9 (glycoprotein IX platelet). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 63.5), Lung (RPKM 9.4) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gp9 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121792842..121794452)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (120235500..120237110)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (119680671..119682006)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 92 Neighboring gene uncharacterized LOC100910604 Neighboring gene EF-hand and coiled-coil domain containing 1 Neighboring gene RAB43, member RAS oncogene family Neighboring gene ISY1 splicing factor homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Detection of autoantibodies against platelet glycoproteins in patients with immune thrombocytopenic purpura by flow cytometric immunobead array. He Y, et al. Clin Chim Acta, 2013 Jan 16. PMID 23103637
    2. A point mutation in glycoprotein IX coding sequence (Cys73 (TGT) to Tyr(TAT)) causes impaired surface expression of GPIb/IX/V complex in two families with Bernard-Soulier syndrome. Noda M, et al. Thromb Haemost, 1996 Dec. PMID 8972003
    3. Patients with Bernard-Soulier syndrome and different severity of the bleeding phenotype. Boeckelmann D, et al. Blood Cells Mol Dis, 2017 Sep. PMID 28131619
    4. Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome. Wright SD, et al. Blood, 1993 May 1. PMID 8481514
    5. The vascular biology of the glycoprotein Ib-IX-V complex. Berndt MC, et al. Thromb Haemost, 2001 Jul. PMID 11487006

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blood coagulation, intrinsic pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in megakaryocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of glycoprotein Ib-IX-V complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    platelet glycoprotein IX
    Names
    glycoprotein 9 (platelet)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031825.2 → NP_001026995.1  platelet glycoprotein IX precursor

      See identical proteins and their annotated locations for NP_001026995.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      Q4AEG0
      Related
      ENSRNOP00000013282.3, ENSRNOT00000013282.7
      Conserved Domains (3) summary
      smart00013
      Location:31 → 65
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:58 → 88
      LRR_1; leucine-rich repeat [structural motif]
      cl15307
      Location:97 → 134
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      121792842..121794452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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