Ackr1 atypical chemokine receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ackr1provided by RGD
Full Name: atypical chemokine receptor 1provided by RGD
Primary source: RGD:1596198
See related: EnsemblRapid:ENSRNOG00000069330 AllianceGenome:RGD:1596198
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Darc
Summary: Predicted to enable C-C chemokine binding activity. Predicted to be involved in inflammatory response and regulation of chemokine production. Predicted to be located in early endosome; membrane; and recycling endosome. Human ortholog(s) of this gene implicated in Plasmodium vivax malaria and malaria. Orthologous to human ACKR1 (atypical chemokine receptor 1 (Duffy blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 43.4), Brain (RPKM 43.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (88314735..88316354, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (85782396..85784015, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (91827310..91828875, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DARC plays a role in the inflammation of skin tissue under venous hypertension.
Title: Duffy antigen / receptor for chemokines correlates with inflammatory reaction in rats with venous hypertension: implication for the pathogenesis of primary chronic venous disease.
The level of DARC in tissue and the degree of inflammatory reaction of venous hypertension have a positive correlation. DARC may promote the development of venous hypertension inflammation through augmenting the adhesion and migration of leukocytes.
Title: [Experimental study of Duffy antigen receptor for chemokines in tissue and the inflammatory reaction of limb with venous hypertension].

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General gene information

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Markers

BE095854 (e-PCR)
- UniSTS:260615

RH138358 (e-PCR)
- UniSTS:220445

AA162249 (e-PCR), detects polymorphism
- UniSTS:143021

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of chemokine production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of chemokine production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: atypical chemokine receptor 1

Names: Duffy blood group, atypical chemokine receptor; Duffy blood group, chemokine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398729.1 → NP_001385658.1 atypical chemokine receptor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I5ZL85, A6JG85

Related

ENSRNOP00000078656.1, ENSRNOT00000117393.2

Conserved Domains (1) summary

cd15010
Location:58 → 314

7tmA_ACKR1_DARC; Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G protein-coupled receptors