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    Ap1s2 adaptor related protein complex 1 subunit sigma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302671, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ap1s2provided by RGD
    Official Full Name
    adaptor related protein complex 1 subunit sigma 2provided by RGD
    Primary source
    RGD:1561862
    See related
    EnsemblRapid:ENSRNOG00000038686 AllianceGenome:RGD:1561862
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561862
    Summary
    Predicted to enable clathrin adaptor activity. Predicted to be involved in synaptic vesicle budding from endosome. Predicted to act upstream of or within several processes, including adipose tissue development; fat cell differentiation; and visual learning. Predicted to be located in Golgi apparatus. Predicted to be part of AP-1 adaptor complex. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 5. Orthologous to human AP1S2 (adaptor related protein complex 1 subunit sigma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 106.9), Spleen (RPKM 95.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap1s2 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (34204601..34230819, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (30572746..30598961, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (32329883..32376301, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 5B Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 Neighboring gene uncharacterized LOC120099291 Neighboring gene uncharacterized LOC120099257 Neighboring gene ring finger protein 138 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. σ1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue. Baltes J, et al. J Cell Sci, 2014 Aug 15. PMID 24928897
    2. AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. Glyvuk N, et al. EMBO J, 2010 Apr 21. PMID 20203623, Free PMC Article
    3. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. Page LJ, et al. J Cell Biol, 1999 Sep 6. PMID 10477754, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables clathrin adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle budding from endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synaptic vesicle recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AP-1 complex subunit sigma-2
    Names
    adaptor-related protein complex 1, sigma 2 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127531.2 → NP_001121003.1  AP-1 complex subunit sigma-2

      See identical proteins and their annotated locations for NP_001121003.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166480
      UniProtKB/TrEMBL
      A6K2M2, B2GV08, F7F749
      Related
      ENSRNOP00000063764.1, ENSRNOT00000065075.5
      Conserved Domains (1) summary
      cd14831
      Location:2 → 144
      AP1_sigma; AP-1 complex subunit sigma

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      34204601..34230819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099658.2 → XP_038955586.1  AP-1 complex subunit sigma-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5U3, A6K2M3
      Related
      ENSRNOP00000100135.1, ENSRNOT00000174079.1
      Conserved Domains (1) summary
      cd14831
      Location:2 → 144
      AP1_sigma; AP-1 complex subunit sigma

    2. XM_006256862.5 → XP_006256924.1  AP-1 complex subunit sigma-2 isoform X2

      See identical proteins and their annotated locations for XP_006256924.1

      Related
      ENSRNOP00000100405.1, ENSRNOT00000147578.1
      Conserved Domains (1) summary
      cd14831
      Location:2 → 142
      AP1_sigma; AP-1 complex subunit sigma

    3. XM_039099659.2 → XP_038955587.1  AP-1 complex subunit sigma-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5U3, A6K2M3
      Related
      ENSRNOP00000070442.1, ENSRNOT00000081652.3
      Conserved Domains (1) summary
      cd14831
      Location:2 → 144
      AP1_sigma; AP-1 complex subunit sigma

    4. XM_039099660.2 → XP_038955588.1  AP-1 complex subunit sigma-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5U3, A6K2M3
      Conserved Domains (1) summary
      cd14831
      Location:2 → 144
      AP1_sigma; AP-1 complex subunit sigma

    RNA

    1. XR_005497961.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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