Bst1 bone marrow stromal cell antigen 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bst1provided by RGD
Official Full Name: bone marrow stromal cell antigen 1provided by RGD
Primary source: RGD:620344
See related: EnsemblRapid:ENSRNOG00000003064 AllianceGenome:RGD:620344
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NAD+ nucleotidase, cyclic ADP-ribose generating and phosphorus-oxygen lyase activity. Predicted to be involved in several processes, including positive regulation of B cell proliferation; regulation of calcium-mediated signaling; and regulation of neutrophil chemotaxis. Predicted to be located in uropod. Predicted to be active in plasma membrane. Orthologous to human BST1 (bone marrow stromal cell antigen 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 247.1), Spleen (RPKM 125.9) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (71466179..71482671, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (67253706..67270203, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (71798218..71814540, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	ISO Inferred from Sequence Orthology more info
enables phosphorus-oxygen lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of B cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
located_in uropod	IEA Inferred from Electronic Annotation more info
located_in uropod	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

Names: ADP-ribosyl cyclase 2; BST-1; bone marrow stromal antigen 1; cADPr hydrolase 2; cyclic ADP-ribose hydrolase 2

NP_110475.1

EC 3.2.2.6

XP_038948409.1

EC 3.2.2.6

XP_038948410.1

EC 3.2.2.6

XP_038948411.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030848.2 → NP_110475.1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor

See identical proteins and their annotated locations for NP_110475.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q63072

UniProtKB/TrEMBL

A6IJP1, F1LSX3

Related

ENSRNOP00000004094.6, ENSRNOT00000004094.8

Conserved Domains (1) summary

pfam02267
Location:41 → 269

Rib_hydrolayse; ADP-ribosyl cyclase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

71466179..71482671 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092482.2 → XP_038948410.1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X2

UniProtKB/TrEMBL

F1LSX3

Related

ENSRNOP00000101299.1, ENSRNOT00000166715.1

Conserved Domains (1) summary

pfam02267
Location:41 → 238

Rib_hydrolayse; ADP-ribosyl cyclase
XM_039092481.2 → XP_038948409.1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1

Related

ENSRNOP00000089976.2, ENSRNOT00000097924.2

Conserved Domains (1) summary

pfam02267
Location:41 → 236

Rib_hydrolayse; ADP-ribosyl cyclase
XM_039092483.2 → XP_038948411.1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X3

Conserved Domains (1) summary

cl08346
Location:41 → 179

Rib_hydrolase; ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38