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    Mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294520, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mical1provided by RGD
    Official Full Name
    microtubule associated monooxygenase, calponin and LIM domain containing 1provided by RGD
    Primary source
    RGD:1309386
    See related
    EnsemblRapid:ENSRNOG00000000307 AllianceGenome:RGD:1309386
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nical; MICAL-1
    Summary
    Predicted to enable several functions, including FAD binding activity; SH3 domain binding activity; and enzyme binding activity. Predicted to be involved in several processes, including actin filament depolymerization; negative regulation of protein phosphorylation; and sulfur oxidation. Predicted to be located in several cellular components, including endosome membrane; hippocampal mossy fiber expansion; and midbody. Predicted to be active in actin filament. Orthologous to human MICAL1 (microtubule associated monooxygenase, calponin and LIM domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 172.3), Spleen (RPKM 82.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mical1 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (46547983..46568487)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (44974137..44986089)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (46199981..46211930)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene adenylate kinase 9 Neighboring gene uncharacterized LOC120098942 Neighboring gene zinc finger and BTB domain containing 24 Neighboring gene sphingomyelin phosphodiesterase 2 Neighboring gene peptidylprolyl isomerase like 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Modulation of MICAL Monooxygenase Activity by its Calponin Homology Domain: Structural and Mechanistic Insights. Alqassim SS, et al. Sci Rep, 2016 Mar 3. PMID 26935886, Free PMC Article
    2. Properties and catalytic activities of MICAL1, the flavoenzyme involved in cytoskeleton dynamics, and modulation by its CH, LIM and C-terminal domains. Vitali T, et al. Arch Biochem Biophys, 2016 Mar 1. PMID 26845023
    3. Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1. Zucchini D, et al. Arch Biochem Biophys, 2011 Nov. PMID 21864500
    4. Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporal epilepsy and pilocarpine-induced rat model. Luo J, et al. Synapse, 2011 Nov. PMID 21638339
    5. Structure and activity of the axon guidance protein MICAL. Nadella M, et al. Proc Natl Acad Sci U S A, 2005 Nov 15. PMID 16275926, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In an epilepsy model, optical density values of MICAL-1 expression decreases at all time points after kindling, compared to the normal group.
      Title: Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporal epilepsy and pilocarpine-induced rat model.
    2. Tesults implicate MICALs in neuronal regeneration and support the possibility to attenuate axon repulsion in the injured spinal cord.
      Title: MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat.
    3. Using the microtubule depolymerizing drug nocodazole we detected a link between MICAL-1 and -3, and the microtubule cytoskeleton.
      Title: The MICAL proteins and rab1: a possible link to the cytoskeleton?
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables F-actin monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH oxidase H202-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of regulated secretory pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfur oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfur oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in hippocampal mossy fiber expansion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    [F-actin]-monooxygenase MICAL1; F-actin-monooxygenase MICAL1
    Names
    NEDD9 interacting protein with calponin homology and LIM domains
    [F-actin]-methionine sulfoxide oxidase MICAL1
    microtubule associated monoxygenase, calponin and LIM domain containing 1
    molecule interacting with CasL protein 1
    protein-methionine sulfoxide oxidase MICAL1
    NP_001099867.1
    XP_038954550.1
    XP_063135149.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106397.1 → NP_001099867.1  [F-actin]-monooxygenase MICAL1

      See identical proteins and their annotated locations for NP_001099867.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474025
      UniProtKB/Swiss-Prot
      D3ZBP4, D3ZJD1
      Related
      ENSRNOP00000110032.1, ENSRNOT00000129191.1
      Conserved Domains (4) summary
      cd09358
      Location:681 → 734
      LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
      pfam01494
      Location:85 → 122
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:918 → 1045
      DUF3585; Protein of unknown function (DUF3585)
      cd21196
      Location:506 → 611
      CH_MICAL1; calponin homology (CH) domain found in molecule interacting with CasL protein 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      46547983..46568487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098622.2 → XP_038954550.1  F-actin-monooxygenase MICAL1 isoform X1

      Related
      ENSRNOP00000000337.5, ENSRNOT00000000337.6
      Conserved Domains (4) summary
      pfam01494
      Location:85 → 122
      FAD_binding_3; FAD binding domain
      pfam12130
      Location:929 → 1056
      DUF3585; Protein of unknown function (DUF3585)
      cd21196
      Location:506 → 611
      CH_MICAL1; calponin homology (CH) domain found in molecule interacting with CasL protein 1
      cl02475
      Location:681 → 734
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_063279079.1 → XP_063135149.1  F-actin-monooxygenase MICAL1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZBP4.1 GenPept UniProtKB/Swiss-Prot:D3ZBP4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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