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    Dennd4c DENN domain containing 4C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313340, updated on 27-Dec-2024

    Summary

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    Symbol
    Dennd4cprovided by RGD
    Full Name
    DENN domain containing 4Cprovided by RGD
    Primary source
    RGD:1308489
    See related
    EnsemblRapid:ENSRNOG00000008036 AllianceGenome:RGD:1308489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308489
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus; protein localization to plasma membrane; and regulation of Rab protein signal transduction. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and insulin-responsive compartment. Predicted to be part of retromer complex. Predicted to be active in cytoplasmic vesicle. Orthologous to human DENND4C (DENN domain containing 4C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 233.6), Adrenal (RPKM 232.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dennd4c in Genome Data Viewer
    Location:
    5q32
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (106316942..106421484)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (101272298..101369529)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (105100081..105195634)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene perilipin 2 Neighboring gene uncharacterized LOC102547623 Neighboring gene uncharacterized LOC134486947 Neighboring gene ribosomal protein S6 Neighboring gene alkaline ceramidase 2 Neighboring gene uncharacterized LOC134486948 Neighboring gene small ribosomal subunit protein uS10-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Circular RNA-DENND4C in H9c2 cells relieves OGD/R-induced injury by down regulation of microRNA-320. Zhang J, et al. Cell Cycle, 2020 Nov. PMID 33090893, Free PMC Article
    2. Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. Borner GH, et al. J Cell Biol, 2012 Apr 2. PMID 22472443, Free PMC Article
    3. Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation. Klip A, et al. Am J Physiol Cell Physiol, 2014 May 15. PMID 24598362
    4. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. Sano H, et al. J Biol Chem, 2011 May 13. PMID 21454697, Free PMC Article
    5. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA-DENND4C in H9c2 cells relieves OGD/R-induced injury by down regulation of microRNA-320.
      Title: Circular RNA-DENND4C in H9c2 cells relieves OGD/R-induced injury by down regulation of microRNA-320.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in insulin-responsive compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 4C
    Names
    DENN/MADD domain containing 4C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427785.1 → NP_001414714.1  DENN domain-containing protein 4C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K089
      Related
      ENSRNOP00000102197.1, ENSRNOT00000159225.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      106316942..106421484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111089.2 → XP_038967017.1  DENN domain-containing protein 4C isoform X1

      Related
      ENSRNOP00000071348.3, ENSRNOT00000082596.3
      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:193 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:820 → 849
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain

    2. XM_039111092.2 → XP_038967020.1  DENN domain-containing protein 4C isoform X3

      Conserved Domains (4) summary
      smart00801
      Location:559 → 632
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:193 → 276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:820 → 849
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309 → 492
      DENN; DENN (AEX-3) domain

    3. XM_039111090.2 → XP_038967018.1  DENN domain-containing protein 4C isoform X2

      Conserved Domains (4) summary
      smart00801
      Location:323 → 396
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:584 → 613
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:73 → 256
      DENN; DENN (AEX-3) domain
      cl04085
      Location:1 → 40
      uDENN; uDENN domain
    Nucleotide Protein Strain
    Heading Accession and Version

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