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    Hmx2 H6 family homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293538, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hmx2provided by RGD
    Official Full Name
    H6 family homeobox 2provided by RGD
    Primary source
    RGD:1565366
    See related
    EnsemblRapid:ENSRNOG00000020638 AllianceGenome:RGD:1565366
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565366
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including inner ear morphogenesis; positive regulation of cell population proliferation; and positive regulation of mRNA splicing, via spliceosome. Predicted to be active in nucleus. Orthologous to human HMX2 (H6 family homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 34.7) See more
    Orthologs
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    Genomic context

    See Hmx2 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (195749284..195758347)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (186319110..186326771)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (203515605..203523266)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483943 Neighboring gene H6 family homeobox 3 Neighboring gene BUB3 mitotic checkpoint protein Neighboring gene uncharacterized LOC134485182

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in nucleus  

    General protein information

    Preferred Names
    homeobox protein HMX2
    Names
    H6 homeo box 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106303.1 → NP_001099773.1  homeobox protein HMX2

      See identical proteins and their annotated locations for NP_001099773.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6HWX2, D4A578
      Related
      ENSRNOP00000028011.4, ENSRNOT00000028011.7
      Conserved Domains (1) summary
      pfam00046
      Location:152 → 206
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      195749284..195758347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107601.2 → XP_038963529.1  homeobox protein HMX2 isoform X1

      UniProtKB/TrEMBL
      A6HWX2, D4A578
      Conserved Domains (1) summary
      pfam00046
      Location:152 → 206
      Homeobox; Homeobox domain
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