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    Kif19 kinesin family member 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303659, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kif19provided by RGD
    Official Full Name
    kinesin family member 19provided by RGD
    Primary source
    RGD:1559936
    See related
    EnsemblRapid:ENSRNOG00000003105 AllianceGenome:RGD:1559936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kif19a; RGD1559936
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in axonemal microtubule depolymerization; microtubule-based movement; and plus-end specific microtubule depolymerization. Predicted to be located in cilium. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Orthologous to human KIF19 (kinesin family member 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 27.6), Testes (RPKM 17.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif19 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (100298912..100325591)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (99800185..99826546)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103308392..103334466)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene tweety family member 2 Neighboring gene small nucleolar RNA SNORA67 Neighboring gene dynein, axonemal, intermediate chain 2 Neighboring gene BTB domain containing 17 Neighboring gene G protein-coupled receptor 142 Neighboring gene G protein-coupled receptor, class C, group 5, member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. KIF19A is a microtubule-depolymerizing kinesin for ciliary length control. Niwa S, et al. Dev Cell, 2012 Dec 11. PMID 23168168
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonemal microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plus-end specific microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF19
    Names
    kinesin family member 19A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415115.1 → NP_001402044.1  kinesin-like protein KIF19

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D4A976
      Related
      ENSRNOP00000004141.7, ENSRNOT00000004141.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      100298912..100325591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086185.2 → XP_038942113.1  kinesin-like protein KIF19 isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:326 → 661
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01370
      Location:11 → 346
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    2. XM_039086184.2 → XP_038942112.1  kinesin-like protein KIF19 isoform X1

      Related
      ENSRNOP00000105564.1, ENSRNOT00000123785.1
      Conserved Domains (2) summary
      COG1196
      Location:319 → 654
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01370
      Location:11 → 339
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    RNA

    1. XR_005489865.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials