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    Shisa2 shisa family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498528, updated on 9-Dec-2024

    Summary

    Official Symbol
    Shisa2provided by RGD
    Official Full Name
    shisa family member 2provided by RGD
    Primary source
    RGD:1561256
    See related
    EnsemblRapid:ENSRNOG00000012521 AllianceGenome:RGD:1561256
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem46; RGD1561256
    Summary
    Predicted to be involved in negative regulation of Wnt signaling pathway and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SHISA2 (shisa family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 76.3), Lung (RPKM 29.0) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Shisa2 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (37982913..37987211)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (33806715..33811013)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (39945095..39949393)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481975 Neighboring gene ribosomal protein S9, pseudogene 9 Neighboring gene eukaryotic translation initiation factor 4B, pseudogene 1 Neighboring gene ATPase phospholipid transporting 8A2 Neighboring gene uncharacterized LOC134481976

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in membrane  

    General protein information

    Preferred Names
    protein shisa-2 homolog
    Names
    shisa homolog 2
    transmembrane protein 46

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191936.1 → NP_001178865.1  protein shisa-2 homolog precursor

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      D3ZWR8
      Related
      ENSRNOP00000016826.3, ENSRNOT00000016826.7
      Conserved Domains (1) summary
      pfam13908
      Location:35 → 147
      Shisa; Wnt and FGF inhibitory regulator

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      37982913..37987211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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