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    Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363509, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgef6provided by RGD
    Official Full Name
    Rac/Cdc42 guanine nucleotide exchange factor 6provided by RGD
    Primary source
    RGD:1359674
    See related
    EnsemblRapid:ENSRNOG00000000869 AllianceGenome:RGD:1359674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in lamellipodium assembly. Predicted to be located in cell-cell junction. Predicted to be active in cytoplasm and lamellipodium. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 165.0), Spleen (RPKM 150.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef6 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (140182734..140302812, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (135145447..135264636, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (159722031..159841344, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 15 Neighboring gene CD40 ligand Neighboring gene small nucleolar RNA, C/D box 61 Neighboring gene RNA binding motif protein, X-linked Neighboring gene transmembrane 9 superfamily member 2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biochemical and functional characterisation of αPIX, a specific regulator of axonal and dendritic branching in hippocampal neurons. Totaro A, et al. Biol Cell, 2012 Sep. PMID 22554054
    2. Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. Kutsche K, et al. Nat Genet, 2000 Oct. PMID 11017088
    3. betaPIX-activated Rac1 stimulates the activation of phospholipase D, which is associated with exocytosis in neuroendocrine cells. Momboisse F, et al. J Cell Sci, 2009 Mar 15. PMID 19261846
    4. c-Cbl regulates αPix-mediated cell migration and invasion. Seong MW, et al. Biochem Biophys Res Commun, 2014 Dec 12. PMID 25450678
    5. Affixin activates Rac1 via betaPIX in C2C12 myoblast. Matsuda C, et al. FEBS Lett, 2008 Apr 9. PMID 18325335

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. c-Cbl negatively regulates alphaPix-mediated cell migration and invasion; the lack of c-Cbl in C6 and A172 glioma cells is responsible for their malignant behavior
      Title: c-Cbl regulates αPix-mediated cell migration and invasion.
    2. alphaPIX and GIT2 are required for neuronal differentiation.
      Title: Biochemical and functional characterisation of αPIX, a specific regulator of axonal and dendritic branching in hippocampal neurons.
    3. betaPix is identified as the guanine nucleotide-exchange factor integrating Rac1 activation to PLD1 and the exocytotic process.
      Title: betaPIX-activated Rac1 stimulates the activation of phospholipase D, which is associated with exocytosis in neuroendocrine cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 6
    Names
    Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005565.2 → NP_001005565.2  rho guanine nucleotide exchange factor 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q5XXR3
      Related
      ENSRNOP00000084113.2, ENSRNOT00000103631.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      140182734..140302812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099908.2 → XP_038955836.1  rho guanine nucleotide exchange factor 6 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GGI3
      Conserved Domains (7) summary
      cd12060
      Location:186 → 242
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:266 → 443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:474 → 572
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:596 → 625
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:626 → 712
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:139 → 184
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21265
      Location:25 → 141
      CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

    2. XM_008773653.4 → XP_008771875.1  rho guanine nucleotide exchange factor 6 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GGI3
      Related
      ENSRNOP00000088717.2, ENSRNOT00000111102.2
      Conserved Domains (8) summary
      cd12060
      Location:186 → 242
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      smart00033
      Location:29 → 129
      CH; Calponin homology domain
      cd00160
      Location:266 → 443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:474 → 572
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:491 → 572
      PH; PH domain
      pfam16523
      Location:652 → 738
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:596 → 649
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:139 → 184
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    3. XM_008773652.4 → XP_008771874.1  rho guanine nucleotide exchange factor 6 isoform X4

      UniProtKB/TrEMBL
      D3ZWQ8
      Conserved Domains (8) summary
      cd12060
      Location:186 → 242
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      smart00033
      Location:29 → 129
      CH; Calponin homology domain
      cd00160
      Location:266 → 443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:474 → 572
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:491 → 572
      PH; PH domain
      pfam16523
      Location:659 → 745
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:593 → 656
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:139 → 184
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    4. XM_039099907.2 → XP_038955835.1  rho guanine nucleotide exchange factor 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZX43
      Conserved Domains (7) summary
      cd12060
      Location:186 → 242
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:266 → 443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:474 → 572
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:598 → 667
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:668 → 754
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:139 → 184
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21265
      Location:25 → 141
      CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

    5. XM_008773651.4 → XP_008771873.1  rho guanine nucleotide exchange factor 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZX43
      Related
      ENSRNOP00000001158.8, ENSRNOT00000001158.9
      Conserved Domains (8) summary
      cd12060
      Location:186 → 242
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      smart00033
      Location:29 → 129
      CH; Calponin homology domain
      cd00160
      Location:266 → 443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:474 → 572
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:491 → 572
      PH; PH domain
      pfam16523
      Location:694 → 780
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:598 → 691
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:139 → 184
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    6. XM_039099906.2 → XP_038955834.1  rho guanine nucleotide exchange factor 6 isoform X2

      UniProtKB/TrEMBL
      D3ZWQ8
      Conserved Domains (7) summary
      cd12060
      Location:186 → 242
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:266 → 443
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:474 → 572
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:598 → 674
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:675 → 761
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:139 → 184
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21265
      Location:25 → 141
      CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

    7. XM_063280154.1 → XP_063136224.1  rho guanine nucleotide exchange factor 6 isoform X8

    8. XM_017602114.3 → XP_017457603.1  rho guanine nucleotide exchange factor 6 isoform X7

      UniProtKB/Swiss-Prot
      Q5XXR3
      Conserved Domains (5) summary
      cd12060
      Location:8 → 64
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:88 → 265
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:296 → 394
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:420 → 520
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:523 → 609
      betaPIX_CC; betaPIX coiled coil

    9. XM_063280155.1 → XP_063136225.1  rho guanine nucleotide exchange factor 6 isoform X9

    10. XM_039099910.2 → XP_038955838.1  rho guanine nucleotide exchange factor 6 isoform X7

      UniProtKB/Swiss-Prot
      Q5XXR3
      Conserved Domains (5) summary
      cd12060
      Location:8 → 64
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:88 → 265
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:296 → 394
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:420 → 520
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:523 → 609
      betaPIX_CC; betaPIX coiled coil

    11. XM_008773654.4 → XP_008771876.1  rho guanine nucleotide exchange factor 6 isoform X7

      UniProtKB/Swiss-Prot
      Q5XXR3
      Conserved Domains (5) summary
      cd12060
      Location:8 → 64
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:88 → 265
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:296 → 394
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:420 → 520
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:523 → 609
      betaPIX_CC; betaPIX coiled coil

    12. XM_039099909.2 → XP_038955837.1  rho guanine nucleotide exchange factor 6 isoform X7

      UniProtKB/Swiss-Prot
      Q5XXR3
      Conserved Domains (5) summary
      cd12060
      Location:8 → 64
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:88 → 265
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:296 → 394
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:420 → 520
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:523 → 609
      betaPIX_CC; betaPIX coiled coil

    13. XM_063280158.1 → XP_063136228.1  rho guanine nucleotide exchange factor 6 isoform X13

      UniProtKB/TrEMBL
      A0A8I6G8W1

    14. XM_063280157.1 → XP_063136227.1  rho guanine nucleotide exchange factor 6 isoform X12

      UniProtKB/TrEMBL
      A0A8I6APF5
      Related
      ENSRNOP00000096317.1, ENSRNOT00000096866.2

    15. XM_063280156.1 → XP_063136226.1  rho guanine nucleotide exchange factor 6 isoform X11

    16. XM_039099911.1 → XP_038955839.1  rho guanine nucleotide exchange factor 6 isoform X10

      Conserved Domains (4) summary
      cd00160
      Location:5 → 179
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:210 → 308
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:334 → 434
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:437 → 523
      betaPIX_CC; betaPIX coiled coil
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XXR3.1 GenPept UniProtKB/Swiss-Prot:Q5XXR3

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