Slc17a9 solute carrier family 17 member 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc17a9provided by RGD
Official Full Name: solute carrier family 17 member 9provided by RGD
Primary source: RGD:1311940
See related: EnsemblRapid:ENSRNOG00000010275 AllianceGenome:RGD:1311940
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: VNUT; RGD1311940
Summary: Predicted to enable purine nucleotide transmembrane transporter activity. Acts upstream of or within ATP export. Predicted to be located in chromaffin granule membrane. Predicted to be active in lysosomal membrane and mucin granule. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human SLC17A9 (solute carrier family 17 member 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 36.6), Liver (RPKM 33.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (188211106..188233553)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (167839246..167857462)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (176228433..176246971)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that release of ATP from periodontal ligament cells via VNUT is important for nociceptive transduction during orthodontic treatment
Title: Vesicular nucleotide transporter mediates adenosine triphosphate release in compressed human periodontal ligament fibroblast cells and participates in tooth movement-induced nociception in rats.
These results suggest that VNUT plays a role in ATP accumulation in dorsal root ganglion neurons
Title: Expression profile of vesicular nucleotide transporter (VNUT, SLC17A9) in subpopulations of rat dorsal root ganglion neurons.
These results demonstrate that intestinal L cells express VNUT (vesicular nucleotide transporter )and suggest that L cells are purinergic in nature and secrete nucleotides.
Title: Immunological identification of vesicular nucleotide transporter in intestinal L cells.
VNUT mediates transport of ATP into synaptic vesicles of hippocampal neurons
Title: Functional and anatomical identification of a vesicular transporter mediating neuronal ATP release.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables ADP transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables guanine nucleotide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables guanine nucleotide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables purine nucleotide uniporter activity	ISO Inferred from Sequence Orthology more info
enables purine nucleotide uniporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ADP transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ADP transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ATP export	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect ATP export	ISO Inferred from Sequence Orthology more info
involved_in ATP transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ATP transport	ISO Inferred from Sequence Orthology more info
involved_in guanine nucleotide transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within guanine nucleotide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in lysosomal protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in purine nucleotide import into lysosome	ISO Inferred from Sequence Orthology more info
involved_in purine nucleotide import into lysosome	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromaffin granule membrane	ISO Inferred from Sequence Orthology more info
located_in chromaffin granule membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mucin granule	IEA Inferred from Electronic Annotation more info
is_active_in mucin granule	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISS Inferred from Sequence or Structural Similarity more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: voltage-gated purine nucleotide uniporter SLC17A9

Names: Vesicular nucleotide transporter; Voltage-gated purine nucleotide uniporter SLC17A9; solute carrier family 17 (vesicular nucleotide transporter), member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108613.1 → NP_001102083.1 voltage-gated purine nucleotide uniporter SLC17A9

See identical proteins and their annotated locations for NP_001102083.1

Status: PROVISIONAL

Source sequence(s)

CH474066

UniProtKB/Swiss-Prot

P0DX21

UniProtKB/TrEMBL

A6KM79, D3ZUN1

Related

ENSRNOP00000013621.4, ENSRNOT00000013623.7

Conserved Domains (1) summary

cd17380
Location:38 → 433

MFS_SLC17A9_like; Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

188211106..188233553

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105555.2 → XP_038961483.1 voltage-gated purine nucleotide uniporter SLC17A9 isoform X1

Conserved Domains (1) summary

cl28910
Location:38 → 326

MFS; Major Facilitator Superfamily
XM_063284238.1 → XP_063140308.1 voltage-gated purine nucleotide uniporter SLC17A9 isoform X2

UniProtKB/Swiss-Prot

P0DX21

UniProtKB/TrEMBL

A6KM79, D3ZUN1
XM_063284239.1 → XP_063140309.1 voltage-gated purine nucleotide uniporter SLC17A9 isoform X3

Related

ENSRNOP00000104893.1, ENSRNOT00000166635.1
XM_039105556.2 → XP_038961484.1 voltage-gated purine nucleotide uniporter SLC17A9 isoform X4

Conserved Domains (1) summary

cd17380
Location:38 → 405

MFS_SLC17A9_like; Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters
XM_063284240.1 → XP_063140310.1 voltage-gated purine nucleotide uniporter SLC17A9 isoform X5
XM_039105559.2 → XP_038961487.1 voltage-gated purine nucleotide uniporter SLC17A9 isoform X8

Conserved Domains (1) summary

cl28910
Location:38 → 286

MFS; Major Facilitator Superfamily
XM_039105558.2 → XP_038961486.1 voltage-gated purine nucleotide uniporter SLC17A9 isoform X6

Conserved Domains (1) summary

cl28910
Location:42 → 270

MFS; Major Facilitator Superfamily
XM_063284241.1 → XP_063140311.1 voltage-gated purine nucleotide uniporter SLC17A9 isoform X7