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    Itga10 integrin subunit alpha 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310683, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Itga10provided by RGD
    Official Full Name
    integrin subunit alpha 10provided by RGD
    Primary source
    RGD:1305152
    See related
    EnsemblRapid:ENSRNOG00000021217 AllianceGenome:RGD:1305152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable collagen binding activity involved in cell-matrix adhesion and integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to be part of integrin alpha10-beta1 complex. Predicted to be active in external side of plasma membrane. Orthologous to human ITGA10 (integrin subunit alpha 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 4.8), Muscle (RPKM 3.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Itga10 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186871711..186891012)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184182869..184202172)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198772937..198792253)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 11 beta Neighboring gene uncharacterized LOC134485661 Neighboring gene RNA, U2 small nuclear 64 Neighboring gene ankyrin repeat domain 35 Neighboring gene uncharacterized LOC120100888 Neighboring gene protein inhibitor of activated STAT, 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner. Sipilä K, et al. FASEB J, 2014 Aug. PMID 24823363
    2. Integrins: bidirectional, allosteric signaling machines. Hynes RO. Cell, 2002 Sep 20. PMID 12297042
    3. The integrins. Takada Y, et al. Genome Biol, 2007. PMID 17543136, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables collagen binding involved in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrin alpha10-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    integrin alpha-10
    Names
    integrin, alpha 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107699.2 → NP_001101169.2  integrin alpha-10 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZW82
      Related
      ENSRNOP00000028812.7, ENSRNOT00000028812.7
      Conserved Domains (3) summary
      smart00191
      Location:545 → 599
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:166 → 346
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:642 → 1050
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      186871711..186891012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102379.1 → XP_038958307.1  integrin alpha-10 isoform X1

      UniProtKB/TrEMBL
      D3ZW82
      Conserved Domains (3) summary
      smart00191
      Location:414 → 468
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:35 → 215
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:511 → 919
      Integrin_alpha2; Integrin alpha
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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