Eya3 EYA transcriptional coactivator and phosphatase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eya3provided by RGD
Official Full Name: EYA transcriptional coactivator and phosphatase 3provided by RGD
Primary source: RGD:1309932
See related: EnsemblRapid:ENSRNOG00000010396 AllianceGenome:RGD:1309932
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chromatin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in several processes, including negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of DNA repair; and response to ionizing radiation. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human EYA3 (EYA transcriptional coactivator and phosphatase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 123.6), Thymus (RPKM 108.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (150090535..150218855)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (144806523..144934522)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (150833754..150915390)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

Eya3 (e-PCR), detects polymorphism
- UniSTS:234060

AW535236 (e-PCR)
- UniSTS:247205

AI177315 (e-PCR)
- UniSTS:250314

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eyes absent homolog 3

Names: eyes absent 3 homolog

NP_001101380.1

EC 3.1.3.48

NP_001402793.1

EC 3.1.3.48

NP_001402794.1

EC 3.1.3.48

XP_006239087.1

EC 3.1.3.48

XP_006239088.1

EC 3.1.3.48

XP_006239089.1

EC 3.1.3.48

XP_038965712.1

EC 3.1.3.48

XP_038965714.1

EC 3.1.3.48

XP_038965715.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107910.2 → NP_001101380.1 eyes absent homolog 3 isoform 3

See identical proteins and their annotated locations for NP_001101380.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6ISU4, D3ZHX6

Related

ENSRNOP00000109356.1, ENSRNOT00000167995.1

Conserved Domains (1) summary

TIGR01658
Location:239 → 510

EYA-cons_domain; eyes absent protein conserved domain
NM_001415864.1 → NP_001402793.1 eyes absent homolog 3 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2JZ01, A0A8I6AMN9

Related

ENSRNOP00000070857.2, ENSRNOT00000082945.3
NM_001415865.1 → NP_001402794.1 eyes absent homolog 3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

D3ZHX6

Related

ENSRNOP00000053016.4, ENSRNOT00000056170.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

150090535..150218855

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109784.2 → XP_038965712.1 eyes absent homolog 3 isoform X1

UniProtKB/TrEMBL

A0A0G2JZ01

Conserved Domains (2) summary

TIGR01658
Location:336 → 607

EYA-cons_domain; eyes absent protein conserved domain

pfam05109
Location:164 → 304

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
XM_039109786.2 → XP_038965714.1 eyes absent homolog 3 isoform X3

UniProtKB/TrEMBL

D3ZHX6

Conserved Domains (2) summary

TIGR01658
Location:255 → 526

EYA-cons_domain; eyes absent protein conserved domain

cl41773
Location:83 → 200

SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
XM_006239027.5 → XP_006239089.1 eyes absent homolog 3 isoform X3

UniProtKB/TrEMBL

D3ZHX6

Related

ENSRNOP00000109307.1, ENSRNOT00000148895.1

Conserved Domains (2) summary

TIGR01658
Location:255 → 526

EYA-cons_domain; eyes absent protein conserved domain

cl41773
Location:83 → 200

SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
XM_039109787.2 → XP_038965715.1 eyes absent homolog 3 isoform X4

UniProtKB/TrEMBL

A0A0G2JZ01

Conserved Domains (2) summary

TIGR01658
Location:253 → 524

EYA-cons_domain; eyes absent protein conserved domain

pfam05109
Location:81 → 221

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
XM_006239025.5 → XP_006239087.1 eyes absent homolog 3 isoform X2

See identical proteins and their annotated locations for XP_006239087.1

UniProtKB/TrEMBL

A0A0G2JZ01, A0A8I6AMN9

Related

ENSRNOP00000095246.1, ENSRNOT00000097388.2

Conserved Domains (1) summary

TIGR01658
Location:301 → 572

EYA-cons_domain; eyes absent protein conserved domain
XM_006239026.4 → XP_006239088.1 eyes absent homolog 3 isoform X2

See identical proteins and their annotated locations for XP_006239088.1

UniProtKB/TrEMBL

A0A0G2JZ01, A0A8I6AMN9

Conserved Domains (1) summary

TIGR01658
Location:301 → 572

EYA-cons_domain; eyes absent protein conserved domain