Cbln1 cerebellin 1 precursor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cbln1provided by RGD
Official Full Name: cerebellin 1 precursorprovided by RGD
Primary source: RGD:1562813
See related: EnsemblRapid:ENSRNOG00000000010 AllianceGenome:RGD:1562813
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including cerebellar granule cell differentiation; modulation of chemical synaptic transmission; and regulation of synapse assembly. Predicted to act upstream of or within establishment of localization in cell; positive regulation of synapse assembly; and protein secretion. Predicted to be located in extracellular region and postsynaptic membrane. Predicted to be active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and synaptic cleft. Orthologous to human CBLN1 (cerebellin 1 precursor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 227.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (35782151..35785960)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (19608763..19612572)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (20607507..20611316)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results determined the crystal structures of the trimeric C1q-like domain of cerebellin-1, and the first complete ectodomain of GluD2. Cerebellin binds to the LNS6 domain of alpha- and beta-neurexin-1 through a high-affinity interaction that involves its highly flexible N-terminal domain.
Title: Conformational Plasticity in the Transsynaptic Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex.
study supports the hypothesis that developmental hypothyroxinemia and hypothyroidism reduce PF-PC synapses, which may be attributed to the downregulation of Neurexin1/Cbln1/GluD2 tripartite complex.
Title: Developmental Hypothyroxinemia and Hypothyroidism Reduce Parallel Fiber-Purkinje Cell Synapses in Rat Offspring by Downregulation of Neurexin1/Cbln1/GluD2 Tripartite Complex.
Precerebellin-related genes and precerebellin 1 peptide in the adrenal gland of the rat: expression pattern, localization, developmental regulation and effects on corticosteroidogenesis.
Title: Precerebellin-related genes and precerebellin 1 peptide in the adrenal gland of the rat: expression pattern, localization, developmental regulation and effects on corticosteroidogenesis.
Using QPCR, the highest expression of Cbln1 gene was demonstrated in hypothalamus and pancreatic islets, a somewhat lower one in the anterior pituitary and thyroid, while the lowest was in adrenal cortex, testis and ovary.
Title: Precerebellin-related genes and precerebellin 1 peptide in endocrine glands of the rat - pattern of their expression.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:464655 (e-PCR)
- UniSTS:464655

Cbln1 (e-PCR), detects polymorphism
- UniSTS:464655

Cbln1 (e-PCR), detects polymorphism
- UniSTS:525884

Cbln1 (e-PCR), detects polymorphism
- UniSTS:525885

Cbln1 (e-PCR), detects polymorphism
- UniSTS:498499

RH142530 (e-PCR)
- UniSTS:231777

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cerebellar granule cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cerebellar granule cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of synapse structure	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of synapse structure	ISO Inferred from Sequence Orthology more info
involved_in maintenance of synapse structure	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inhibitory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inhibitory synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in trans-synaptic signaling, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic cleft	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic cleft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cerebellin-1

Names: cerebellin 1 precursor protein; precerebellin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.