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    Trim67 tripartite motif-containing 67 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307938, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trim67provided by RGD
    Official Full Name
    tripartite motif-containing 67provided by RGD
    Primary source
    RGD:1560667
    See related
    EnsemblRapid:ENSRNOG00000019024 AllianceGenome:RGD:1560667
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560667
    Summary
    Predicted to enable zinc ion binding activity. Predicted to act upstream of or within negative regulation of Ras protein signal transduction; positive regulation of neuron projection development; and positive regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human TRIM67 (tripartite motif containing 67). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 9.9), Adrenal (RPKM 7.3) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Trim67 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (69659857..69703290)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (52763991..52805906)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (57554665..57593401)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 89, member A Neighboring gene transfer RNA alanine (anticodon AGC) 43 Neighboring gene 40S small subunit processome assembly factor 1 Neighboring gene glyceronephosphate O-acyltransferase Neighboring gene exocyst complex component 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    tripartite motif-containing protein 67

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135715.1NP_001129187.1  tripartite motif-containing protein 67

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      D3ZTX1
      Conserved Domains (5) summary
      smart00502
      Location:336462
      BBC; B-Box C-terminal domain
      cd00063
      Location:515591
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00643
      Location:290329
      zf-B_box; B-box zinc finger
      cd12889
      Location:588759
      SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
      cl17238
      Location:747
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      69659857..69703290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601304.3XP_017456793.1  tripartite motif-containing protein 67 isoform X3

      Related
      ENSRNOP00000032148.5, ENSRNOT00000032359.6
    2. XM_063278073.1XP_063134143.1  tripartite motif-containing protein 67 isoform X1

    3. XM_063278074.1XP_063134144.1  tripartite motif-containing protein 67 isoform X2