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    Foxp3 forkhead box P3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317382, updated on 9-Dec-2024

    Summary

    Official Symbol
    Foxp3provided by RGD
    Official Full Name
    forkhead box P3provided by RGD
    Primary source
    RGD:1562112
    See related
    EnsemblRapid:ENSRNOG00000011702 AllianceGenome:RGD:1562112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562112
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including establishment of endothelial blood-brain barrier; negative regulation of defense response to virus; and response to rapamycin. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Used to study intrahepatic cholangiocarcinoma. Biomarker of Korean hemorrhagic fever; bronchial disease (multiple); graft-versus-host disease; hypertension; and hypothyroidism. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 46.7), Thymus (RPKM 33.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Foxp3 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17580380..17601181, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14908494..14924994, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15753175..15768648, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099258 Neighboring gene synaptophysin Neighboring gene calcium voltage-gated channel subunit alpha1 F Neighboring gene coiled-coil domain containing 22 Neighboring gene protein phosphatase 1 regulatory subunit 3F Neighboring gene ribosomal protein L3, pseudogene 5 Neighboring gene Fus RNA binding protein like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables NFAT protein binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables histone acetyltransferase binding  
    enables histone deacetylase binding  
    enables identical protein binding  
    enables metal ion binding  
    enables protein homodimerization activity  
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription corepressor activity  
    Items 1 - 25 of 84
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell homeostasis  
    acts_upstream_of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  
    involved_in CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  
    acts_upstream_of CD4-positive, alpha-beta T cell differentiation  
    acts_upstream_of CD4-positive, alpha-beta T cell proliferation  
    acts_upstream_of DNA-templated transcription  
    acts_upstream_of_or_within T cell activation  
    involved_in T cell activation  
    acts_upstream_of T cell anergy  
    acts_upstream_of_or_within T cell mediated immunity  
    acts_upstream_of T cell proliferation  
    acts_upstream_of_or_within T cell receptor signaling pathway  
    acts_upstream_of T cell tolerance induction  
    acts_upstream_of alpha-beta T cell proliferation  
    acts_upstream_of_or_within chromatin remodeling  
    involved_in establishment of endothelial blood-brain barrier PubMed 
    acts_upstream_of_or_within gene expression  
    acts_upstream_of immature T cell proliferation in thymus  
    acts_upstream_of inflammatory response  
    acts_upstream_of isotype switching to IgE isotypes  
    acts_upstream_of lymphocyte proliferation  
    acts_upstream_of_or_within myeloid cell homeostasis  
    acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation  
    involved_in negative regulation of CREB transcription factor activity  
    involved_in negative regulation of DNA-binding transcription factor activity  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of NF-kappaB transcription factor activity  
    involved_in negative regulation of T cell cytokine production  
    acts_upstream_of_or_within negative regulation of T cell proliferation  
    involved_in negative regulation of T cell proliferation  
    involved_in negative regulation of T-helper 17 cell differentiation  
    acts_upstream_of_or_within negative regulation of alpha-beta T cell proliferation  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of chronic inflammatory response  
    involved_in negative regulation of cytokine production  
    involved_in negative regulation of defense response to virus PubMed 
    acts_upstream_of_or_within negative regulation of gene expression  
    involved_in negative regulation of immune response  
    acts_upstream_of_or_within negative regulation of inflammatory response  
    acts_upstream_of_or_within negative regulation of interleukin-10 production  
    involved_in negative regulation of interleukin-10 production  
    involved_in negative regulation of interleukin-17 production  
    acts_upstream_of_or_within negative regulation of interleukin-2 production  
    involved_in negative regulation of interleukin-2 production  
    acts_upstream_of_or_within negative regulation of interleukin-4 production  
    involved_in negative regulation of interleukin-4 production  
    acts_upstream_of_or_within negative regulation of interleukin-5 production  
    acts_upstream_of_or_within negative regulation of interleukin-6 production  
    acts_upstream_of_or_within negative regulation of isotype switching to IgE isotypes  
    acts_upstream_of_or_within negative regulation of lymphocyte proliferation  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of tumor necrosis factor production  
    acts_upstream_of_or_within negative regulation of type II interferon production  
    involved_in negative regulation of type II interferon production  
    acts_upstream_of_or_within positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  
    acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell differentiation  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of T cell anergy  
    acts_upstream_of_or_within positive regulation of T cell tolerance induction  
    acts_upstream_of_or_within positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of immature T cell proliferation in thymus  
    acts_upstream_of_or_within positive regulation of interleukin-4 production  
    acts_upstream_of_or_within positive regulation of peripheral T cell tolerance induction  
    acts_upstream_of_or_within positive regulation of regulatory T cell differentiation  
    involved_in positive regulation of regulatory T cell differentiation  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transforming growth factor beta1 production  
    involved_in regulation of T cell anergy  
    acts_upstream_of_or_within regulation of immunoglobulin production  
    acts_upstream_of_or_within regulation of isotype switching to IgG isotypes  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    acts_upstream_of regulatory T cell differentiation  
    involved_in regulatory T cell differentiation  
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to rapamycin PubMed 
    involved_in response to virus  
    acts_upstream_of_or_within tolerance induction  
    acts_upstream_of_or_within tolerance induction to self antigen  
    acts_upstream_of transcription by RNA polymerase II  
    acts_upstream_of transforming growth factor beta1 production  
    Items 1 - 25 of 84
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in nucleus  
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108250.2NP_001101720.1  forkhead box protein P3

      See identical proteins and their annotated locations for NP_001101720.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6G4G9, D4Q8I1
      Related
      ENSRNOP00000015641.5, ENSRNOT00000015641.8
      Conserved Domains (3) summary
      PHA03247
      Location:1137
      PHA03247; large tegument protein UL36; Provisional
      pfam16159
      Location:193260
      FOXP-CC; FOXP coiled-coil domain
      cd20066
      Location:337417
      FH_FOXP3; Forkhead (FH) domain found in Forkhead box protein P3 (FOXP3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      17580380..17601181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099794.2XP_038955722.1  forkhead box protein P3 isoform X1

      Conserved Domains (2) summary
      pfam16159
      Location:221288
      FOXP-CC; FOXP coiled-coil domain
      cd20066
      Location:365445
      FH_FOXP3; Forkhead (FH) domain found in Forkhead box protein P3 (FOXP3) and similar proteins
    2. XM_063280054.1XP_063136124.1  forkhead box protein P3 isoform X1

    3. XM_063280055.1XP_063136125.1  forkhead box protein P3 isoform X2

    4. XM_063280056.1XP_063136126.1  forkhead box protein P3 isoform X2

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