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    Pde6c phosphodiesterase 6C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361752, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pde6cprovided by RGD
    Official Full Name
    phosphodiesterase 6Cprovided by RGD
    Primary source
    RGD:1309844
    See related
    EnsemblRapid:ENSRNOG00000016593 AllianceGenome:RGD:1309844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling and visual perception. Predicted to act upstream of or within phototransduction, visible light; retinal cone cell development; and sensory perception of light stimulus. Human ortholog(s) of this gene implicated in cone-rod dystrophy. Orthologous to human PDE6C (phosphodiesterase 6C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 29.0), Liver (RPKM 3.7) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pde6c in Genome Data Viewer
    Location:
    1q53
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (245322015..245377874)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (235909583..235965435)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (256822099..256885879)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene free fatty acid receptor 4 Neighboring gene retinol binding protein 4 Neighboring gene FRA10A associated CGG repeat 1 Neighboring gene RGD1561251

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Study of rod- and cone-driven oscillatory potentials in mice. Lei B, et al. Invest Ophthalmol Vis Sci, 2006 Jun. PMID 16723493
    2. Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5. Cote RH. Int J Impot Res, 2004 Jun. PMID 15224133
    3. Rod-driven OFF pathway responses in the distal retina: dark-adapted flicker electroretinogram in mouse. Lei B. PLoS One, 2012. PMID 22937111, Free PMC Article
    4. Mouse model resources for vision research. Won J, et al. J Ophthalmol, 2011. PMID 21052544, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phototransduction, visible light ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retinal cone cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of light stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
    Names
    phosphodiesterase 6C, cGMP specific, cone, alpha prime
    NP_001402932.1
    XP_063124726.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416003.1 → NP_001402932.1  cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I183, D3ZLC7
      Related
      ENSRNOP00000022317.7, ENSRNOT00000022317.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      245322015..245377874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268656.1 → XP_063124726.1  cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6R9, A6I183
      Related
      ENSRNOP00000087890.1, ENSRNOT00000117700.2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108522.1: Suppressed sequence

      Description
      NM_001108522.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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