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    Ddr1 discoidin domain receptor tyrosine kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25678, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ddr1provided by RGD
    Official Full Name
    discoidin domain receptor tyrosine kinase 1provided by RGD
    Primary source
    RGD:2252
    See related
    EnsemblRapid:ENSRNOG00000057125 AllianceGenome:RGD:2252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cak; Drd1; PTK3D
    Summary
    Predicted to enable collagen binding activity and protein tyrosine kinase collagen receptor activity. Involved in animal organ regeneration; collagen-activated tyrosine kinase receptor signaling pathway; and skin development. Located in basolateral plasma membrane and brush border. Used to study idiopathic pulmonary fibrosis. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in breast carcinoma; lung non-small cell carcinoma; osteosarcoma; and skin melanoma. Orthologous to human DDR1 (discoidin domain receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 202.8), Brain (RPKM 117.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Ddr1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3047269..3069277)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3042494..3064442)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3553430..3574959)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553505 Neighboring gene uncharacterized LOC134483849 Neighboring gene hypothetical LOC100310783 Neighboring gene uncharacterized LOC134483850 Neighboring gene general transcription factor 2H subunit 4 Neighboring gene valyl-tRNA synthetase 2, mitochondrial

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables collagen binding  
    enables collagen binding  
    enables collagen binding  
    enables collagen binding  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables metal ion binding  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables stem cell factor receptor activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 27
    Items 1 - 25 of 64
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    involved_in animal organ regeneration PubMed 
    involved_in axon development  
    acts_upstream_of_or_within axon development  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in branching involved in mammary gland duct morphogenesis  
    acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis  
    involved_in cell population proliferation  
    acts_upstream_of cell population proliferation  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway PubMed 
    acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in ear development  
    acts_upstream_of_or_within ear development  
    involved_in embryo implantation  
    acts_upstream_of_or_within embryo implantation  
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in lactation  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in mammary gland alveolus development  
    acts_upstream_of_or_within mammary gland alveolus development  
    involved_in multicellular organism development  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in neuron projection extension  
    acts_upstream_of_or_within neuron projection extension  
    acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation  
    involved_in peptidyl-tyrosine autophosphorylation  
    involved_in peptidyl-tyrosine autophosphorylation  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within protein autophosphorylation  
    involved_in protein autophosphorylation  
    involved_in regulation of cell growth  
    acts_upstream_of_or_within regulation of cell growth  
    involved_in regulation of cell-matrix adhesion  
    acts_upstream_of_or_within regulation of cell-matrix adhesion  
    involved_in regulation of extracellular matrix disassembly  
    involved_in regulation of extracellular matrix disassembly  
    involved_in regulation of extracellular matrix disassembly  
    involved_in skin development PubMed 
    involved_in smooth muscle cell migration  
    involved_in smooth muscle cell migration  
    involved_in smooth muscle cell migration  
    involved_in smooth muscle cell-matrix adhesion  
    involved_in smooth muscle cell-matrix adhesion  
    involved_in smooth muscle cell-matrix adhesion  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    involved_in wound healing, spreading of cells  
    involved_in wound healing, spreading of cells  
    involved_in wound healing, spreading of cells  
    Items 1 - 25 of 64
    Component Evidence Code Pubs
    located_in basolateral plasma membrane PubMed 
    located_in brush border PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of receptor complex  
    part_of receptor complex  
    part_of receptor complex  

    General protein information

    Preferred Names
    epithelial discoidin domain-containing receptor 1
    Names
    CD167 antigen-like family member A
    cell adhesion kinase
    discoidin domain receptor family, member 1
    discoidin receptor tyrosine kinase
    epithelial discoidin domain receptor 1
    neurotrophic tyrosine kinase receptor type 4
    protein-tyrosine kinase 3
    protein-tyrosine kinase PTK-3
    tyrosine kinase DDR
    tyrosine-protein kinase CAK
    NP_001159494.1
    NP_037269.2
    XP_017457045.1
    XP_017457046.1
    XP_017457047.1
    XP_017457048.1
    XP_017457049.1
    XP_017457050.1
    XP_038954390.1
    XP_063135052.1
    XP_063135053.1
    XP_063135054.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166022.1NP_001159494.1  epithelial discoidin domain-containing receptor 1 precursor

      See identical proteins and their annotated locations for NP_001159494.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC166604, BX883047, CB613563
      UniProtKB/Swiss-Prot
      Q63474
      UniProtKB/TrEMBL
      A0A0G2KAB1, A6KT95, Q6MG19
      Conserved Domains (2) summary
      cd05096
      Location:601904
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:58185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    2. NM_013137.2NP_037269.2  epithelial discoidin domain-containing receptor 1 precursor

      See identical proteins and their annotated locations for NP_037269.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC166604, BX883047, DN935615
      UniProtKB/Swiss-Prot
      Q63474
      UniProtKB/TrEMBL
      A0A0G2KAB1, A6KT95, Q6MG19
      Related
      ENSRNOP00000075331.1, ENSRNOT00000089417.3
      Conserved Domains (2) summary
      cd05096
      Location:601904
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:58185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3047269..3069277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601558.3XP_017457047.1  epithelial discoidin domain-containing receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q63474
      UniProtKB/TrEMBL
      A0A0G2KAB1, A6KT95, Q6MG19
      Conserved Domains (2) summary
      cd05096
      Location:601904
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:58185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    2. XM_063278982.1XP_063135052.1  epithelial discoidin domain-containing receptor 1 isoform X2

      UniProtKB/Swiss-Prot
      Q63474
      UniProtKB/TrEMBL
      A0A0G2K7S7
    3. XM_039098462.2XP_038954390.1  epithelial discoidin domain-containing receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q63474
      UniProtKB/TrEMBL
      A0A0G2KAB1, A6KT95, Q6MG19
      Conserved Domains (2) summary
      cd05096
      Location:601904
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:58185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    4. XM_063278983.1XP_063135053.1  epithelial discoidin domain-containing receptor 1 isoform X2

      UniProtKB/Swiss-Prot
      Q63474
      UniProtKB/TrEMBL
      A0A0G2K7S7
    5. XM_017601556.3XP_017457045.1  epithelial discoidin domain-containing receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q63474
      UniProtKB/TrEMBL
      A0A0G2KAB1, A6KT95, Q6MG19
      Conserved Domains (2) summary
      cd05096
      Location:601904
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:58185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    6. XM_017601559.3XP_017457048.1  epithelial discoidin domain-containing receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q63474
      UniProtKB/TrEMBL
      A0A0G2KAB1, A6KT95, Q6MG19
      Conserved Domains (2) summary
      cd05096
      Location:601904
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:58185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    7. XM_017601560.3XP_017457049.1  epithelial discoidin domain-containing receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q63474
      UniProtKB/TrEMBL
      A0A0G2KAB1, A6KT95, Q6MG19
      Conserved Domains (2) summary
      cd05096
      Location:601904
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:58185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    8. XM_017601561.3XP_017457050.1  epithelial discoidin domain-containing receptor 1 isoform X2

      UniProtKB/Swiss-Prot
      Q63474
      UniProtKB/TrEMBL
      A0A0G2K7S7
      Related
      ENSRNOP00000098213.1, ENSRNOT00000120573.2
      Conserved Domains (2) summary
      cd05096
      Location:564867
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:58185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    9. XM_017601557.3XP_017457046.1  epithelial discoidin domain-containing receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q63474
      UniProtKB/TrEMBL
      A0A0G2KAB1, A6KT95, Q6MG19
      Conserved Domains (2) summary
      cd05096
      Location:601904
      PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
      cd00057
      Location:58185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    10. XM_063278984.1XP_063135054.1  epithelial discoidin domain-containing receptor 1 isoform X2

      UniProtKB/Swiss-Prot
      Q63474
      UniProtKB/TrEMBL
      A0A0G2K7S7
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