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    Lrrc69 leucine rich repeat containing 69 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500415, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc69provided by RGD
    Official Full Name
    leucine rich repeat containing 69provided by RGD
    Primary source
    RGD:1583733
    See related
    EnsemblRapid:ENSRNOG00000006498 AllianceGenome:RGD:1583733
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in intracellular signal transduction. Orthologous to human LRRC69 (leucine rich repeat containing 69). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 69.7) and Adrenal (RPKM 3.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc69 in Genome Data Viewer
    Location:
    5q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (32820840..32979176, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (28023591..28181963, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (28133066..28321877, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member A1, pseudogene 2 Neighboring gene solute carrier family 26 member 7 Neighboring gene OTU deubiquitinase 6B Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 69

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134624.1 → NP_001128096.1  leucine-rich repeat-containing protein 69

      See identical proteins and their annotated locations for NP_001128096.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473962
      UniProtKB/TrEMBL
      A6II94, D3Z998
      Related
      ENSRNOP00000008656.5, ENSRNOT00000008656.7
      Conserved Domains (3) summary
      sd00033
      Location:16 → 38
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:130 → 170
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:131 → 188
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      32820840..32979176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110544.2 → XP_038966472.1  leucine-rich repeat-containing protein 69 isoform X4

      Conserved Domains (2) summary
      COG4886
      Location:3 → 225
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:23 → 45
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_039110541.2 → XP_038966469.1  leucine-rich repeat-containing protein 69 isoform X2

      Conserved Domains (2) summary
      COG4886
      Location:3 → 225
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:23 → 45
      LRR_RI; leucine-rich repeat [structural motif]

    3. XM_017593569.3 → XP_017449058.1  leucine-rich repeat-containing protein 69 isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q640
      Related
      ENSRNOP00000076349.2, ENSRNOT00000093515.3

    4. XM_039110545.2 → XP_038966473.1  leucine-rich repeat-containing protein 69 isoform X5

      Conserved Domains (2) summary
      COG4886
      Location:19 → 142
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:16 → 38
      LRR_RI; leucine-rich repeat [structural motif]

    5. XM_039110543.2 → XP_038966471.1  leucine-rich repeat-containing protein 69 isoform X3

      Conserved Domains (2) summary
      COG4886
      Location:3 → 226
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:23 → 45
      LRR_RI; leucine-rich repeat [structural motif]

    6. XM_039110542.2 → XP_038966470.1  leucine-rich repeat-containing protein 69 isoform X3

      Conserved Domains (2) summary
      COG4886
      Location:3 → 226
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:23 → 45
      LRR_RI; leucine-rich repeat [structural motif]

    7. XM_039110546.2 → XP_038966474.2  leucine-rich repeat-containing protein 69 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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