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    Adat2 adenosine deaminase, tRNA-specific 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adat2provided by RGD
    Official Full Name
    adenosine deaminase, tRNA-specific 2provided by RGD
    Primary source
    RGD:1309642
    See related
    AllianceGenome:RGD:1309642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Deadc1
    Summary
    Predicted to enable tRNA-specific adenosine-34 deaminase activity and zinc ion binding activity. Predicted to be involved in tRNA wobble adenosine to inosine editing. Orthologous to human ADAT2 (adenosine deaminase tRNA specific 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 71.5), Spleen (RPKM 60.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adat2 in Genome Data Viewer
    Location:
    1p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (9774680..9795376)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (7954520..7975254)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (7726447..7743112)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene alpha-L-fucosidase 2 Neighboring gene peroxisomal biogenesis factor 3 Neighboring gene uncharacterized LOC120098785 Neighboring gene cofilin 1, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tRNA-specific adenosine-34 deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-specific adenosine-34 deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA wobble adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble adenosine to inosine editing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-specific adenosine deaminase 2
    Names
    deaminase domain containing 1
    NP_001108500.1
    XP_038937004.1
    XP_038937010.1
    XP_038937016.1
    XP_063122049.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115028.3 → NP_001108500.1  tRNA-specific adenosine deaminase 2

      See identical proteins and their annotated locations for NP_001108500.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      B0BMY9
      Conserved Domains (1) summary
      COG0590
      Location:23 → 173
      TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      9774680..9795376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265979.1 → XP_063122049.1  tRNA-specific adenosine deaminase 2 isoform X2

    2. XM_039081076.2 → XP_038937004.1  tRNA-specific adenosine deaminase 2 isoform X1

      Conserved Domains (1) summary
      COG0590
      Location:23 → 161
      TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

    3. XM_039081088.2 → XP_038937016.1  tRNA-specific adenosine deaminase 2 isoform X4

      Conserved Domains (1) summary
      COG0590
      Location:4 → 114
      TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

    4. XM_039081082.2 → XP_038937010.1  tRNA-specific adenosine deaminase 2 isoform X3

      Conserved Domains (1) summary
      COG0590
      Location:4 → 126
      TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_010054015.1 RNA Sequence

    2. XR_010054014.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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