Bud23 BUD23, rRNA methyltransferase and ribosome maturation factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bud23provided by RGD
Official Full Name: BUD23, rRNA methyltransferase and ribosome maturation factorprovided by RGD
Primary source: RGD:1589742
See related: EnsemblRapid:ENSRNOG00000033700 AllianceGenome:RGD:1589742
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wbscr22
Summary: Predicted to enable protein heterodimerization activity and rRNA (guanine) methyltransferase activity. Predicted to be involved in positive regulation of rRNA processing and rRNA (guanine-N7)-methylation. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 74.3), Muscle (RPKM 72.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (27266093..27277300)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (21629551..21640758)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (24669626..24680833)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138619 (e-PCR)
- UniSTS:220706

RH134623 (e-PCR)
- UniSTS:217902

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables rRNA (guanine) methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (guanine) methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in rRNA (guanine-N7)-methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA (guanine-N7)-methylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable 18S rRNA (guanine-N(7))-methyltransferase

Names: Williams Beuren syndrome chromosome region 22

NP_001129215.1

EC 2.1.1.309

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135743.1 → NP_001129215.1 probable 18S rRNA (guanine-N(7))-methyltransferase

See identical proteins and their annotated locations for NP_001129215.1

Status: PROVISIONAL

Source sequence(s)

BC160891

UniProtKB/TrEMBL

B1H275

Related

ENSRNOP00000047461.3, ENSRNOT00000044449.7

Conserved Domains (3) summary

COG2227
Location:18 → 91

UbiG; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]

pfam08241
Location:58 → 128

Methyltransf_11; Methyltransferase domain

pfam12589
Location:204 → 279

WBS_methylT; Methyltransferase involved in Williams-Beuren syndrome