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    Zcwpw2 zinc finger CW-type and PWWP domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681381, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zcwpw2provided by RGD
    Official Full Name
    zinc finger CW-type and PWWP domain containing 2provided by RGD
    Primary source
    RGD:1596709
    See related
    EnsemblRapid:ENSRNOG00000053820 AllianceGenome:RGD:1596709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable methylated histone binding activity. Orthologous to human ZCWPW2 (zinc finger CW-type and PWWP domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 27.4), Adrenal (RPKM 21.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zcwpw2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (126506855..126651270, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (117628838..117773096, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (126080907..126402056, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480110 Neighboring gene uncharacterized LOC120093118 Neighboring gene uncharacterized LOC134480246 Neighboring gene uncharacterized LOC120094353 Neighboring gene 5-azacytidine induced 2 Neighboring gene uncharacterized LOC120094354 Neighboring gene C-x(9)-C motif containing 1 Neighboring gene uncharacterized LOC108351794

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Bithell A, et al. Brain Res Dev Brain Res, 2003 Dec 19. PMID 14643017
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CW-type PWWP domain protein 2; zinc finger CW-type and PWWP domain containing 2
    Names
    zinc finger, CW type with PWWP domain 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430695.1 → NP_001417624.1  zinc finger CW-type and PWWP domain containing 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GHL5

    2. NM_001430696.1 → NP_001417625.1  zinc finger CW-type and PWWP domain containing 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GHL5

    3. NM_001430697.1 → NP_001417626.1  zinc finger CW-type and PWWP domain containing 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GHL5

    4. NM_001430698.1 → NP_001417627.1  zinc finger CW-type and PWWP domain containing 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GHL5

    5. NM_001430699.1 → NP_001417628.1  zinc finger CW-type and PWWP domain containing 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K432

    6. NM_001430700.1 → NP_001417629.1  zinc finger CW-type and PWWP domain containing 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K432

    7. NM_001430701.1 → NP_001417630.1  zinc finger CW-type and PWWP domain containing 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K432

    8. NM_001430703.1 → NP_001417632.1  zinc finger CW-type and PWWP domain containing 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I3T3

    9. NM_001430704.1 → NP_001417633.1  zinc finger CW-type and PWWP domain containing 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I3T3

    10. NM_001430705.1 → NP_001417634.1  zinc finger CW-type and PWWP domain containing 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I3T3

    RNA

    1. NR_190985.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      126506855..126651270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266479.1 → XP_063122549.1  zinc finger CW-type PWWP domain protein 2 isoform X2

    2. XM_063266481.1 → XP_063122551.1  zinc finger CW-type PWWP domain protein 2 isoform X6

    3. XM_039082852.2 → XP_038938780.1  zinc finger CW-type PWWP domain protein 2 isoform X5

      UniProtKB/TrEMBL
      A6I3T3
      Conserved Domains (2) summary
      pfam07496
      Location:22 → 69
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:88 → 174
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    4. XM_039082849.2 → XP_038938777.1  zinc finger CW-type PWWP domain protein 2 isoform X2

      Conserved Domains (2) summary
      pfam07496
      Location:22 → 69
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:89 → 152
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    5. XM_039082848.2 → XP_038938776.1  zinc finger CW-type PWWP domain protein 2 isoform X1

      Related
      ENSRNOP00000102512.1, ENSRNOT00000140628.1
      Conserved Domains (2) summary
      pfam07496
      Location:22 → 69
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:88 → 174
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    6. XM_039082851.2 → XP_038938779.1  zinc finger CW-type PWWP domain protein 2 isoform X4

      UniProtKB/TrEMBL
      A6I3T3
      Related
      ENSRNOP00000108924.1, ENSRNOT00000141317.1
      Conserved Domains (2) summary
      pfam07496
      Location:22 → 69
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:89 → 152
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    7. XM_039082850.2 → XP_038938778.1  zinc finger CW-type PWWP domain protein 2 isoform X3

      Related
      ENSRNOP00000072884.3, ENSRNOT00000089732.3
      Conserved Domains (2) summary
      pfam07496
      Location:22 → 69
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:88 → 174
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    8. XM_063266478.1 → XP_063122548.1  zinc finger CW-type PWWP domain protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K432

    9. XM_063266476.1 → XP_063122546.1  zinc finger CW-type PWWP domain protein 2 isoform X1

    10. XM_063266480.1 → XP_063122550.1  zinc finger CW-type PWWP domain protein 2 isoform X3

      Related
      ENSRNOP00000089746.2, ENSRNOT00000096228.2

    11. XM_063266477.1 → XP_063122547.1  zinc finger CW-type PWWP domain protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GHL5

    RNA

    1. XR_010054512.1 RNA Sequence

    2. XR_005488692.2 RNA Sequence

    3. XR_005488690.2 RNA Sequence

    4. XR_005488689.2 RNA Sequence

    5. XR_005488686.2 RNA Sequence

    6. XR_010054511.1 RNA Sequence

    7. XR_005488687.2 RNA Sequence

    8. XR_005488688.2 RNA Sequence

    9. XR_005488696.2 RNA Sequence

    10. XR_005488695.2 RNA Sequence

    11. XR_005488693.2 RNA Sequence

    12. XR_005488691.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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