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    Grid2ip Grid2 interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288484, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grid2ipprovided by RGD
    Official Full Name
    Grid2 interacting proteinprovided by RGD
    Primary source
    RGD:1310492
    See related
    EnsemblRapid:ENSRNOG00000030927 AllianceGenome:RGD:1310492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of postsynaptic cytosolic calcium ion concentration and regulation of postsynaptic membrane neurotransmitter receptor levels. Predicted to act upstream of or within long-term synaptic depression. Predicted to be located in postsynapse. Predicted to be active in cerebellar granule cell to Purkinje cell synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density, intracellular component. Orthologous to human GRID2IP (Grid2 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 7.9), Lung (RPKM 1.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Grid2ip in Genome Data Viewer
    Location:
    12p11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (16274809..16317319, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (11166567..11203765, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (13221334..13257365, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol lipase, beta Neighboring gene KDEL endoplasmic reticulum protein retention receptor 2 Neighboring gene uncharacterized LOC134481326 Neighboring gene zinc finger DHHC-type palmitoyltransferase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Group II metabotropic glutamate receptor-mediated regulation of dopamine release from slices of rat nucleus accumbens. Chaki S, et al. Neurosci Lett, 2006 Aug 14. PMID 16781059
    2. Identification and characterization of a novel Delphilin variant with an alternative N-terminus. Yamashita T, et al. Brain Res Mol Brain Res, 2005 Nov 18. PMID 16168524
    3. Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin. Takeuchi T, et al. PLoS One, 2008 May 28. PMID 18509461, Free PMC Article
    4. Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit. Miyagi Y, et al. J Neurosci, 2002 Feb 1. PMID 11826110, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Group II mGluRs may play a significant role in regulating dopamine release in the nucleus accumbens.
      Title: Group II metabotropic glutamate receptor-mediated regulation of dopamine release from slices of rat nucleus accumbens.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within long-term synaptic depression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cerebellar granule cell to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    delphilin
    Names
    glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105910.2 → NP_001099380.2  delphilin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6K1L2, F1LU68
      Related
      ENSRNOP00000039762.3, ENSRNOT00000044378.5
      Conserved Domains (3) summary
      cd00992
      Location:90 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd07355
      Location:199 → 278
      HN_L-delphilin-R2_like; second harmonin_N_like domain (repeat 2) of L-delphilin, and related domains
      pfam02181
      Location:633 → 1001
      FH2; Formin Homology 2 Domain

    2. NM_001415779.1 → NP_001402708.1  delphilin isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6AL96, A6K1L2
      Related
      ENSRNOP00000094031.1, ENSRNOT00000096543.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      16274809..16317319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248866.5 → XP_006248928.1  delphilin isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1R4, A6K1L2
      Related
      ENSRNOP00000085589.1, ENSRNOT00000098048.2
      Conserved Domains (4) summary
      cd00992
      Location:269 → 342
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd07354
      Location:122 → 201
      HN_L-delphilin-R1_like; first harmonin_N_like domain (repeat 1) of L-delphilin, and related domains
      cd07355
      Location:378 → 457
      HN_L-delphilin-R2_like; second harmonin_N_like domain (repeat 2) of L-delphilin, and related domains
      pfam02181
      Location:812 → 1180
      FH2; Formin Homology 2 Domain
    Nucleotide Protein Strain
    Heading Accession and Version

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