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    Irgc immunity related GTPase cinema [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308428, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Irgcprovided by RGD
    Official Full Name
    immunity related GTPase cinemaprovided by RGD
    Primary source
    RGD:1311107
    See related
    EnsemblRapid:ENSRNOG00000024257 AllianceGenome:RGD:1311107
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ifgge; Irgc1; RGD1311107
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in positive regulation of flagellated sperm motility. Predicted to be located in lipid droplet and sperm mitochondrial sheath. Orthologous to human IRGC (immunity related GTPase cinema). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 942.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Irgc in Genome Data Viewer
    Location:
    1q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (89148056..89151838, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (80020114..80025797, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (81291739..81295517, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene SMG9 nonsense mediated mRNA decay factor Neighboring gene transfer RNA alanine (anticodon AGC) 66 Neighboring gene uncharacterized LOC134482902 Neighboring gene plasminogen activator, urokinase receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sperm mitochondrial sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm mitochondrial sheath ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    interferon-inducible GTPase 5
    Names
    immunity-related GTPase cinema 1
    immunity-related GTPase family, cinema 1
    interferon-gamma-inducible GTPase Ifgge protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014016.1 → NP_001014038.1  interferon-inducible GTPase 5

      See identical proteins and their annotated locations for NP_001014038.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079061
      UniProtKB/Swiss-Prot
      Q6AYF9
      UniProtKB/TrEMBL
      J7PCJ5
      Related
      ENSRNOP00000083551.1, ENSRNOT00000103829.2
      Conserved Domains (2) summary
      cd04104
      Location:53 → 249
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      cl40481
      Location:17 → 75
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      89148056..89151838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228426.5 → XP_006228488.1  interferon-inducible GTPase 5 isoform X1

      See identical proteins and their annotated locations for XP_006228488.1

      UniProtKB/Swiss-Prot
      Q6AYF9
      UniProtKB/TrEMBL
      J7PCJ5
      Conserved Domains (2) summary
      cd04104
      Location:53 → 249
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      cl40481
      Location:17 → 75
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    2. XM_039111344.2 → XP_038967272.1  interferon-inducible GTPase 5 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYF9
      UniProtKB/TrEMBL
      J7PCJ5
      Related
      ENSRNOP00000087872.1, ENSRNOT00000105042.2
      Conserved Domains (2) summary
      cd04104
      Location:53 → 249
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      cl40481
      Location:17 → 75
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    3. XM_063261352.1 → XP_063117422.1  interferon-inducible GTPase 5 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYF9
      UniProtKB/TrEMBL
      J7PCJ5

    4. XM_006228427.5 → XP_006228489.1  interferon-inducible GTPase 5 isoform X1

      See identical proteins and their annotated locations for XP_006228489.1

      UniProtKB/Swiss-Prot
      Q6AYF9
      UniProtKB/TrEMBL
      J7PCJ5
      Conserved Domains (2) summary
      cd04104
      Location:53 → 249
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      cl40481
      Location:17 → 75
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

    5. XM_008758927.4 → XP_008757149.1  interferon-inducible GTPase 5 isoform X1

      See identical proteins and their annotated locations for XP_008757149.1

      UniProtKB/Swiss-Prot
      Q6AYF9
      UniProtKB/TrEMBL
      J7PCJ5
      Related
      ENSRNOP00000030295.3, ENSRNOT00000030900.5
      Conserved Domains (2) summary
      cd04104
      Location:53 → 249
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      cl40481
      Location:17 → 75
      YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYF9.1 GenPept UniProtKB/Swiss-Prot:Q6AYF9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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