Trim16 tripartite motif-containing 16 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trim16provided by RGD
Official Full Name: tripartite motif-containing 16provided by RGD
Primary source: RGD:1309749
See related: EnsemblRapid:ENSRNOG00000071275 AllianceGenome:RGD:1309749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity; NACHT domain binding activity; and interleukin-1 binding activity. Predicted to be involved in several processes, including positive regulation of keratinocyte differentiation; positive regulation of metabolic process; and positive regulation of retinoic acid receptor signaling pathway. Predicted to be located in PML body; cytosol; and plasma membrane. Orthologous to several human genes including TRIM16 (tripartite motif containing 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 116.2), Kidney (RPKM 53.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (47985235..48008242)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (47485982..47509010)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (49231660..49254653)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
Title: Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway.
Title: A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables NACHT domain binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1 binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to growth hormone	ISO Inferred from Sequence Orthology more info
involved_in response to organophosphorus	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tripartite motif-containing protein 16

Names: tripartite motif protein 16

NP_001128505.1

EC 2.3.2.27

XP_063125085.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135033.4 → NP_001128505.1 tripartite motif-containing protein 16

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6GI85, D3ZW47

Related

ENSRNOP00000098406.1, ENSRNOT00000120793.2

Conserved Domains (2) summary

pfam00643
Location:118 → 158

zf-B_box; B-box zinc finger

cd12890
Location:358 → 539

SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)