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    Thap7 THAP domain containing 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Thap7provided by RGD
    Official Full Name
    THAP domain containing 7provided by RGD
    Primary source
    RGD:1308061
    See related
    EnsemblRapid:ENSRNOG00000037967 AllianceGenome:RGD:1308061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including C2H2 zinc finger domain binding activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in chromatin organization and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; nuclear membrane; and nuclear speck. Predicted to be active in nucleus. Orthologous to human THAP7 (THAP domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 51.1), Kidney (RPKM 48.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Thap7 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96986720..96990375)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83482958..83486136)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87399430..87403381, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X 6 Neighboring gene leucine rich repeat containing 74B Neighboring gene translation machinery-associated protein 16 pseudogene Neighboring gene leucine zipper like post translational regulator 1 Neighboring gene AIF family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. Miele A, et al. J Cell Biochem, 2007 Sep 1. PMID 17577209
    2. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables general transcription initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphorylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    THAP domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105863.2 → NP_001099333.2  THAP domain-containing protein 7

      See identical proteins and their annotated locations for NP_001099333.2

      Status: VALIDATED

      Source sequence(s)
      AW916308, BC168998
      UniProtKB/TrEMBL
      A0A8I6AQX2, A0A8I6B5E1, A6JSL3
      Related
      ENSRNOP00000097153.1, ENSRNOT00000116617.2
      Conserved Domains (1) summary
      smart00980
      Location:4 → 93
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96986720..96990375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088075.2 → XP_038944003.1  THAP domain-containing protein 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AQX2
      Conserved Domains (1) summary
      smart00980
      Location:4 → 108
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

    2. XM_063270324.1 → XP_063126394.1  THAP domain-containing protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AQX2

    3. XM_008768864.3 → XP_008767086.2  THAP domain-containing protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQX2, G3V9P2
      Conserved Domains (1) summary
      smart00980
      Location:4 → 127
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

    4. XM_063270325.1 → XP_063126395.1  THAP domain-containing protein 7 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AQX2

    5. XM_039088076.2 → XP_038944004.1  THAP domain-containing protein 7 isoform X6

    6. XM_039088074.2 → XP_038944002.1  THAP domain-containing protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQX2
      Related
      ENSRNOP00000054562.4, ENSRNOT00000057751.6
      Conserved Domains (1) summary
      smart00980
      Location:4 → 125
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

    7. XM_039088077.2 → XP_038944005.1  THAP domain-containing protein 7 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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