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    Enpep glutamyl aminopeptidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64017, updated on 9-Dec-2024

    Summary

    Symbol
    Enpepprovided by RGD
    Full Name
    glutamyl aminopeptidaseprovided by RGD
    Primary source
    RGD:621228
    See related
    EnsemblRapid:ENSRNOG00000051854 AllianceGenome:RGD:621228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables aminopeptidase activity and peptide binding activity. Involved in peptide catabolic process and protein processing. Located in brush border membrane. Orthologous to human ENPEP (glutamyl aminopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 612.5), Lung (RPKM 262.1) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Enpep in Genome Data Viewer
    Location:
    2q42
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (220456258..220526218, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (217781985..217851947, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (233667253..233743866, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350289 Neighboring gene paired-like homeodomain 2 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene uncharacterized LOC134485964 Neighboring gene uncharacterized LOC134485764 Neighboring gene proteasome 20S subunit beta 7, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminopeptidase activity PubMed 
    enables aminopeptidase activity  
    enables aminopeptidase activity  
    enables metalloaminopeptidase activity  
    enables metalloaminopeptidase activity  
    enables metalloaminopeptidase activity  
    enables metalloaminopeptidase activity  
    enables metallopeptidase activity  
    enables peptidase activity  
    enables peptide binding  
    enables peptide binding PubMed 
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in angiogenesis  
    acts_upstream_of_or_within angiogenesis  
    involved_in cell migration  
    acts_upstream_of_or_within cell migration  
    involved_in cell migration  
    involved_in cell population proliferation  
    acts_upstream_of_or_within cell population proliferation  
    involved_in cell population proliferation  
    involved_in glomerulus development  
    involved_in glomerulus development  
    involved_in peptide catabolic process  
    involved_in peptide catabolic process PubMed 
    involved_in protein processing PubMed 
    involved_in proteolysis  
    involved_in proteolysis  
    involved_in regulation of blood pressure  
    involved_in regulation of systemic arterial blood pressure by renin-angiotensin  
    involved_in regulation of systemic arterial blood pressure by renin-angiotensin  
    involved_in regulation of systemic arterial blood pressure by renin-angiotensin  
    Component Evidence Code Pubs
    located_in apical part of cell  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in brush border  
    located_in brush border  
    located_in brush border membrane PubMed 
    is_active_in cytoplasm  
    located_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle  
    located_in external side of plasma membrane  
    located_in external side of plasma membrane  
    is_active_in extracellular space  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    glutamyl aminopeptidase
    Names
    AP-A
    EAP
    aminopeptidase A
    NP_071587.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022251.2NP_071587.2  glutamyl aminopeptidase

      Status: VALIDATED

      Source sequence(s)
      AF146044, AF214568, BC066663, CB747518, CK481363
      UniProtKB/Swiss-Prot
      P50123, Q64200, Q9JLQ7, Q9JLQ9, Q9QV24
      UniProtKB/TrEMBL
      A0A0G2JTI8, A6HVN5
      Related
      ENSRNOP00000068728.2, ENSRNOT00000087062.3
      Conserved Domains (3) summary
      cd09601
      Location:92537
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:84474
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:608922
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      220456258..220526218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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