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    Rsph9 radial spoke head component 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316238, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rsph9provided by RGD
    Official Full Name
    radial spoke head component 9provided by RGD
    Primary source
    RGD:1310693
    See related
    EnsemblRapid:ENSRNOG00000019474 AllianceGenome:RGD:1310693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310693
    Summary
    Predicted to be involved in cilium assembly and cilium movement involved in cell motility. Predicted to be located in sperm flagellum. Predicted to be part of radial spoke head 1 and radial spoke head 3. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 12. Orthologous to human RSPH9 (radial spoke head component 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 90.7), Lung (RPKM 49.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rsph9 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22337681..22350515)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14840115..14852950)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17224589..17245093)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2, pseudogene 6 Neighboring gene MAD2L1 binding protein Neighboring gene mitochondrial ribosomal protein S18A Neighboring gene uncharacterized LOC134480341

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities. Castleman VH, et al. Am J Hum Genet, 2009 Feb. PMID 19200523, Free PMC Article
    2. DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes. Dougherty GW, et al. Am J Respir Cell Mol Biol, 2016 Aug. PMID 26909801, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axonemal central apparatus assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in radial spoke assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+2 motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinocilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke head ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke head 1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke head 3 ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    radial spoke head protein 9 homolog
    Names
    radial spoke head 9 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108205.2 → NP_001101675.2  radial spoke head protein 9 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2KAI9, A6JIT7, A6JIT8, D4A5Y7
      Related
      ENSRNOP00000075414.2, ENSRNOT00000080816.3
      Conserved Domains (1) summary
      pfam04712
      Location:17 → 274
      Radial_spoke; Radial spokehead-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      22337681..22350515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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