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    Tnfsf14 TNF superfamily member 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnfsf14provided by RGD
    Official Full Name
    TNF superfamily member 14provided by RGD
    Primary source
    RGD:1588572
    See related
    AllianceGenome:RGD:1588572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tnlg1d
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; cytokine activity; and identical protein binding activity. Predicted to be involved in cell surface receptor signaling pathway; cellular response to mechanical stimulus; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including T cell costimulation; positive regulation of T cell chemotaxis; and positive regulation of myoblast fusion. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human TNFSF14 (TNF superfamily member 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 18.3), Thymus (RPKM 14.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnfsf14 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (2155270..2160100, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (2068295..2073128, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9761363..9765461)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene BRCA1/BRCA2-containing complex subunit 3 Neighboring gene Cd70 molecule Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene complement C3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Liu W, et al. Structure, 2014 Sep 2. PMID 25087510, Free PMC Article
    2. LIGHT/TNFSF14 enhances adipose tissue inflammatory responses through its interaction with HVEM. Kim HM, et al. FEBS Lett, 2011 Feb 4. PMID 21236258
    3. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. Tamada K, et al. J Immunol, 2000 Apr 15. PMID 10754304
    4. LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-alpha-mediated human primary hepatocyte apoptosis, but not Fas-mediated apoptosis. Matsui H, et al. J Biol Chem, 2002 Dec 20. PMID 12393901
    5. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Sedy JR, et al. Nat Immunol, 2005 Jan. PMID 15568026

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of T cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor ligand superfamily member 14
    Names
    tumor necrosis factor (ligand) superfamily, member 14
    tumor necrosis factor ligand 1d
    tumor necrosis factor superfamily member 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191803.2 → NP_001178732.1  tumor necrosis factor ligand superfamily member 14

      See identical proteins and their annotated locations for NP_001178732.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6KQR4
      Conserved Domains (1) summary
      pfam00229
      Location:110 → 239
      TNF; TNF(Tumour Necrosis Factor) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      2155270..2160100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083146.2 → XP_038939074.1  tumor necrosis factor ligand superfamily member 14 isoform X1

      Conserved Domains (1) summary
      pfam00229
      Location:96 → 225
      TNF; TNF(tumor Necrosis Factor) family
    Nucleotide Protein Strain
    Heading Accession and Version

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