Fermt1 FERM domain containing kindlin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fermt1provided by RGD
Official Full Name: FERM domain containing kindlin 1provided by RGD
Primary source: RGD:1306816
See related: EnsemblRapid:ENSRNOG00000021274 AllianceGenome:RGD:1306816
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306816
Summary: Predicted to enable actin filament binding activity and integrin binding activity. Predicted to be involved in several processes, including positive regulation of cell adhesion; regulation of gene expression; and regulation of signal transduction. Predicted to be located in cell junction; cell periphery; and cytosol. Predicted to be active in focal adhesion. Human ortholog(s) of this gene implicated in Kindler syndrome; telangiectasis; and vesiculobullous skin disease. Orthologous to human FERMT1 (FERM domain containing kindlin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 68.3), Uterus (RPKM 33.7) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (140624434..140666419, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (120171301..120213555, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (125566744..125607864, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FERM domain containing kindlin 1 knockdown attenuates inflammation induced by intracerebral hemorrhage in rats via NLR family pyrin domain containing 3/nuclear factor kappa B pathway.
Title: FERM domain containing kindlin 1 knockdown attenuates inflammation induced by intracerebral hemorrhage in rats via NLR family pyrin domain containing 3/nuclear factor kappa B pathway.
Kindlin-1 silencing elevated the mechanical and thermal pain thresholds of chronic constriction injury rats.
Title: Kindlin-1 Regulates Astrocyte Activation and Pain Sensitivity in Rats With Neuropathic Pain.
that kindlin-1 is a key protein in the action of hyperbaric oxygen therapy in the treatment of neuropathic pain
Title: Kindlin-1 is a key protein in hyperbaric oxygen therapy for the treatment of neuropathic pain.
results therefore suggest that kindlin-1 is a potential tool for improving axon regeneration after nervous system lesions.
Title: Kindlin-1 enhances axon growth on inhibitory chondroitin sulfate proteoglycans and promotes sensory axon regeneration.

Submit: New GeneRIF Correction

General gene information

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Markers

5830467P10Rik (e-PCR), detects polymorphism
- UniSTS:498215

5830467P10Rik (e-PCR), detects polymorphism
- UniSTS:498216

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in basement membrane organization	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of epithelial cell polarity	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte migration	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of timing of anagen	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fermitin family homolog 1

Names: UNC-112 related protein 1; fermitin family member 1; kindlin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106515.1 → NP_001099985.1 fermitin family homolog 1

See identical proteins and their annotated locations for NP_001099985.1

Status: PROVISIONAL

Source sequence(s)

CH473949

UniProtKB/TrEMBL

A6HQH7, D3ZTV0

Related

ENSRNOP00000028901.5, ENSRNOT00000028901.8

Conserved Domains (5) summary

smart00295
Location:250 → 322

B41; Band 4.1 homologues

cd01237
Location:370 → 494

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

cd13205
Location:564 → 655

FERM_C_fermitin; FERM domain C-lobe of the Fermitin family

pfam00169
Location:378 → 473

PH; PH domain

pfam00373
Location:515 → 570

FERM_M; FERM central domain