Izumo1 izumo sperm-oocyte fusion 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Izumo1provided by RGD
Official Full Name: izumo sperm-oocyte fusion 1provided by RGD
Primary source: RGD:1565454
See related: EnsemblRapid:ENSRNOG00000089371 AllianceGenome:RGD:1565454
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein homodimerization activity. Involved in binding activity of sperm to zona pellucida. Located in plasma membrane. Orthologous to human IZUMO1 (izumo sperm-oocyte fusion 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 121.1) and Muscle (RPKM 7.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105227603..105233357)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (96090817..96096893)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101603222..101608977)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO.
Title: Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO.
four phosphopeptide changes came from Izumo1, the sperm-egg fusion protein, in the cytoplasmic segment of the protein. 2D-PAGE confirmed that Izumo1 is post-translationally modified during epididymal transit.
Title: Analysis of phosphopeptide changes as spermatozoa acquire functional competence in the epididymis demonstrates changes in the post-translational modification of Izumo1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding involved in heterotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding involved in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
enables protein binding involved in heterotypic cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	ISO Inferred from Sequence Orthology more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in single fertilization	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in sperm-egg recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm-egg recognition	ISO Inferred from Sequence Orthology more info
involved_in sperm-egg recognition	ISS Inferred from Sequence or Structural Similarity more info
involved_in syncytium formation by plasma membrane fusion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in acrosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal membrane	ISO Inferred from Sequence Orthology more info
located_in acrosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein complex involved in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
part_of protein complex involved in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: izumo sperm-egg fusion protein 1

Names: OBF; izumo sperm-egg fusion 1; oocyte binding/fusion factor; sperm-specific protein izumo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017514.1 → NP_001017514.1 izumo sperm-egg fusion protein 1 precursor

See identical proteins and their annotated locations for NP_001017514.1

Status: PROVISIONAL

Source sequence(s)

BC079244

UniProtKB/Swiss-Prot

Q6AY06

UniProtKB/TrEMBL

A0A455R7F4, A6JB60

Related

ENSRNOP00000107803.1, ENSRNOT00000160746.1

Conserved Domains (2) summary

pfam15005
Location:22 → 165

IZUMO; Izumo sperm-egg fusion, Ig domain-associated

pfam16706
Location:170 → 255

Izumo-Ig; Izumo-like Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

105227603..105233357

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087504.2 → XP_038943432.1 izumo sperm-egg fusion protein 1 isoform X2

Conserved Domains (2) summary

pfam15005
Location:22 → 165

IZUMO; Izumo sperm-egg fusion, Ig domain-associated

pfam16706
Location:170 → 200

Izumo-Ig; Izumo-like Immunoglobulin domain
XM_039087498.1 → XP_038943426.1 izumo sperm-egg fusion protein 1 isoform X1

Conserved Domains (2) summary

pfam15005
Location:1 → 24

IZUMO; Izumo sperm-egg fusion, Ig domain-associated

pfam16706
Location:29 → 114

Izumo-Ig; Izumo-like Immunoglobulin domain