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    Oma1 OMA1 zinc metallopeptidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298282, updated on 9-Dec-2024

    Summary

    Official Symbol
    Oma1provided by RGD
    Official Full Name
    OMA1 zinc metallopeptidaseprovided by RGD
    Primary source
    RGD:1304821
    See related
    EnsemblRapid:ENSRNOG00000007214 AllianceGenome:RGD:1304821
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304821
    Summary
    Enables metalloendopeptidase activity. Predicted to be involved in several processes, including HRI-mediated signaling; protein processing; and regulation of mitochondrion organization. Predicted to act upstream of or within cristae formation. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane and mitochondrial intermembrane space. Orthologous to human OMA1 (OMA1 zinc metallopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 88.4), Muscle (RPKM 86.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Oma1 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (123312038..123455540)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (118083728..118136980)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (122847624..122900475)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 1 open reading frame 141 Neighboring gene uncharacterized LOC134486958 Neighboring gene small nucleolar RNA U3 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding  
    enables metal ion binding  
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity PubMed 
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    Items 1 - 25 of 47
    Process Evidence Code Pubs
    involved_in HRI-mediated signaling  
    involved_in HRI-mediated signaling  
    involved_in cellular response to stress  
    involved_in cristae formation  
    acts_upstream_of_or_within cristae formation  
    involved_in diet induced thermogenesis  
    involved_in diet induced thermogenesis  
    involved_in diet induced thermogenesis  
    involved_in energy homeostasis  
    involved_in energy homeostasis  
    involved_in glucose metabolic process  
    involved_in glucose metabolic process  
    involved_in glucose metabolic process  
    involved_in integrated stress response signaling  
    involved_in integrated stress response signaling  
    involved_in lipid metabolic process  
    involved_in lipid metabolic process  
    involved_in lipid metabolic process  
    involved_in mitochondrial protein processing  
    involved_in mitochondrial protein processing  
    acts_upstream_of_or_within mitochondrial protein processing  
    involved_in mitochondrial protein processing  
    involved_in mitochondrial protein processing  
    involved_in mitochondrial respiratory chain complex assembly  
    involved_in mitochondrial respiratory chain complex assembly  
    involved_in mitochondrial respiratory chain complex assembly  
    acts_upstream_of_or_within mitochondrion organization  
    involved_in negative regulation of mitochondrial fusion  
    involved_in negative regulation of mitochondrial fusion  
    involved_in negative regulation of mitochondrial fusion  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in protein autoprocessing  
    involved_in protein autoprocessing  
    involved_in protein autoprocessing  
    involved_in protein quality control for misfolded or incompletely synthesized proteins  
    involved_in protein quality control for misfolded or incompletely synthesized proteins  
    involved_in protein quality control for misfolded or incompletely synthesized proteins  
    involved_in proteolysis  
    involved_in regulation of cristae formation  
    involved_in regulation of cristae formation  
    involved_in zymogen activation  
    involved_in zymogen activation  
    involved_in zymogen activation  
    Items 1 - 25 of 47
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    is_active_in mitochondrial intermembrane space  
    located_in mitochondrial membrane  
    located_in mitochondrial membrane  
    located_in mitochondrion  

    General protein information

    Preferred Names
    metalloendopeptidase OMA1, mitochondrial
    Names
    OMA1 homolog, zinc metallopeptidase
    overlapping with the m-AAA protease 1 homolog
    zinc metallopeptidase homolog
    NP_001100139.1
    XP_063143450.1
    XP_063143451.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106669.1NP_001100139.1  metalloendopeptidase OMA1, mitochondrial

      See identical proteins and their annotated locations for NP_001100139.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473998
      UniProtKB/Swiss-Prot
      D3ZS74
      UniProtKB/TrEMBL
      A0A8L2Q3X0
      Conserved Domains (2) summary
      COG0501
      Location:264434
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      pfam01435
      Location:258432
      Peptidase_M48; Peptidase family M48

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      123312038..123455540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287381.1XP_063143451.1  metalloendopeptidase OMA1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q3X0
      Related
      ENSRNOP00000100728.1, ENSRNOT00000128078.1
    2. XM_063287380.1XP_063143450.1  metalloendopeptidase OMA1, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      D3ZS74
      UniProtKB/TrEMBL
      A0A8L2Q3X0
      Related
      ENSRNOP00000009515.5, ENSRNOT00000009516.6

    RNA

    1. XR_010066355.1 RNA Sequence

    2. XR_010066356.1 RNA Sequence

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