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    Cd7 Cd7 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd7provided by RGD
    Official Full Name
    Cd7 moleculeprovided by RGD
    Primary source
    RGD:1310015
    See related
    EnsemblRapid:ENSRNOG00000036674 AllianceGenome:RGD:1310015
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of T cell cytokine production. Predicted to act upstream of or within homeostasis of number of cells within a tissue. Predicted to be located in membrane. Orthologous to human CD7 (CD7 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 198.3), Spleen (RPKM 192.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cd7 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106802373..106805269, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106304046..106306963, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (110229931..110232812, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene dolichyl-phosphate mannosyltransferase subunit 3, regulatory, pseudogene 2 Neighboring gene solute carrier family 16 member 3 Neighboring gene casein kinase 1, delta Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene secreted and transmembrane 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immunologic characterization of CD7-deficient mice. Lee DM, et al. J Immunol, 1998 Jun 15. PMID 9637484
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-cell antigen CD7
    Names
    CD7 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107074.1 → NP_001100544.1  T-cell antigen CD7 precursor

      See identical proteins and their annotated locations for NP_001100544.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      B2RZ54, F7F5G3
      Related
      ENSRNOP00000051817.2, ENSRNOT00000054934.6
      Conserved Domains (2) summary
      cd00096
      Location:25 → 28
      Ig; Ig strand A [structural motif]
      cl11960
      Location:27 → 125
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106802373..106805269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086226.2 → XP_038942154.1  T-cell antigen CD7 isoform X1

      Conserved Domains (2) summary
      cd00096
      Location:12 → 17
      Ig; Ig strand C' [structural motif]
      cl11960
      Location:11 → 71
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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