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    Mbnl2 muscleblind-like splicing regulator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680445, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mbnl2provided by RGD
    Official Full Name
    muscleblind-like splicing regulator 2provided by RGD
    Primary source
    RGD:1591755
    See related
    EnsemblRapid:ENSRNOG00000010737 AllianceGenome:RGD:1591755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity and sequence-specific double-stranded DNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human MBNL2 (muscleblind like splicing regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 537.2), Muscle (RPKM 531.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mbnl2 in Genome Data Viewer
    Location:
    15q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (103792134..103949827)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (97385278..97542924)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (105640097..105797933)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551086 Neighboring gene uncharacterized LOC120097085 Neighboring gene uncharacterized LOC120097086 Neighboring gene uncharacterized LOC120097087 Neighboring gene uncharacterized LOC120097088 Neighboring gene RAP2A, member of RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA binding  
    enables metal ion binding  
    enables sequence-specific double-stranded DNA binding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    muscleblind-like protein 2
    Names
    muscleblind-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111064.2NP_001104534.1  muscleblind-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001104534.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      F2Z3T4
      UniProtKB/TrEMBL
      A6HUI3
      Related
      ENSRNOP00000014300.7, ENSRNOT00000014300.9
      Conserved Domains (1) summary
      smart00356
      Location:178202
      ZnF_C3H1; zinc finger
    2. NM_001415043.1NP_001401972.1  muscleblind-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5Y5P3, A6HUI2
      Related
      ENSRNOP00000077342.1, ENSRNOT00000109835.2
    3. NM_001415044.1NP_001401973.1  muscleblind-like protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6AKC8, A6HUI3
      Related
      ENSRNOP00000094173.1, ENSRNOT00000116108.2
    4. NM_001415045.1NP_001401974.1  muscleblind-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HUI2
      Related
      ENSRNOP00000089857.2, ENSRNOT00000095906.2
    5. NM_001415046.1NP_001401975.1  muscleblind-like protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HUI3
    6. NM_001415047.1NP_001401976.1  muscleblind-like protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HUI3
      Related
      ENSRNOP00000112436.1, ENSRNOT00000160527.1
    7. NM_001415048.1NP_001401977.1  muscleblind-like protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HUI3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      103792134..103949827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274619.1XP_063130689.1  muscleblind-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HUI3
    2. XM_063274622.1XP_063130692.1  muscleblind-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A6HUI3
      Related
      ENSRNOP00000099124.1, ENSRNOT00000173246.1
    3. XM_063274626.1XP_063130696.1  muscleblind-like protein 2 isoform X5

      UniProtKB/TrEMBL
      A6HUI3
    4. XM_063274620.1XP_063130690.1  muscleblind-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HUI3
    5. XM_063274621.1XP_063130691.1  muscleblind-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HUI3
    6. XM_063274624.1XP_063130694.1  muscleblind-like protein 2 isoform X3

      UniProtKB/TrEMBL
      A6HUI2
    7. XM_063274625.1XP_063130695.1  muscleblind-like protein 2 isoform X4

      UniProtKB/TrEMBL
      A6HUI3
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