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    Aox3 aldehyde oxidase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 493909, updated on 9-Dec-2024

    Summary

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    Symbol
    Aox3provided by RGD
    Full Name
    aldehyde oxidase 3provided by RGD
    Primary source
    RGD:1359328
    See related
    EnsemblRapid:ENSRNOG00000014555 AllianceGenome:RGD:1359328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aoh1
    Summary
    Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; molybdopterin cofactor binding activity; and protein homodimerization activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 302.2), Testes (RPKM 109.7) and 5 other tissues See more
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    Genomic context

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    See Aox3 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67158987..67245299)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (59664784..59749701)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65013831..65099433)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 18 Neighboring gene U6 spliceosomal RNA Neighboring gene shugoshin 2 Neighboring gene aldehyde oxidase 1 Neighboring gene uncharacterized LOC120094690 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene protein tyrosine phosphatase 4A1, pseudogene 5 Neighboring gene aldehyde oxidase 4 Neighboring gene uncharacterized LOC103690538 Neighboring gene ribosomal protein L21 like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro. Neumeier M, et al. Biochem Biophys Res Commun, 2006 Nov 24. PMID 17022944
    2. The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa. Kurosaki M, et al. J Biol Chem, 2004 Nov 26. PMID 15383531
    3. Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression. Kurosaki M, et al. Cell Mol Life Sci, 2013 May. PMID 23263164, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The current data indicate that adiponectin reduces AOX1 by activating PPAR-alpha whereas fatty liver disease is associated with elevated hepatic AOX1.
      Title: Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin cofactor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in xenobiotic metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde oxidase 3
    Names
    aldehyde oxidase homolog 1
    azaheterocycle hydroxylase 3
    NP_001008527.2
    XP_038939964.1
    XP_038939965.1
    XP_038939966.1
    XP_038939967.1
    XP_038939968.1
    XP_063123639.1
    XP_063123640.1
    XP_063123641.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008527.2 → NP_001008527.2  aldehyde oxidase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5QE80
      UniProtKB/TrEMBL
      A0A1B0GWV6
      Related
      ENSRNOP00000076035.2, ENSRNOT00000092906.3
      Conserved Domains (1) summary
      TIGR02969
      Location:9 → 1333
      mam_aldehyde_ox; aldehyde oxidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      67158987..67245299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084036.2 → XP_038939964.1  aldehyde oxidase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBF0
      Conserved Domains (1) summary
      TIGR02969
      Location:9 → 1261
      mam_aldehyde_ox; aldehyde oxidase

    2. XM_039084040.2 → XP_038939968.1  aldehyde oxidase 3 isoform X7

      Conserved Domains (1) summary
      TIGR02969
      Location:9 → 736
      mam_aldehyde_ox; aldehyde oxidase

    3. XM_039084037.2 → XP_038939965.1  aldehyde oxidase 3 isoform X2

      UniProtKB/Swiss-Prot
      Q5QE80
      Conserved Domains (1) summary
      TIGR02969
      Location:1 → 1276
      mam_aldehyde_ox; aldehyde oxidase

    4. XM_039084038.2 → XP_038939966.1  aldehyde oxidase 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K1Z5
      Conserved Domains (1) summary
      TIGR02969
      Location:7 → 1158
      mam_aldehyde_ox; aldehyde oxidase

    5. XM_063267571.1 → XP_063123641.1  aldehyde oxidase 3 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K1Z5

    6. XM_063267570.1 → XP_063123640.1  aldehyde oxidase 3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K1Z5
      Related
      ENSRNOP00000076637.2, ENSRNOT00000112101.2

    7. XM_039084039.2 → XP_038939967.1  aldehyde oxidase 3 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K1Z5
      Conserved Domains (1) summary
      TIGR02969
      Location:1 → 1109
      mam_aldehyde_ox; aldehyde oxidase

    8. XM_063267569.1 → XP_063123639.1  aldehyde oxidase 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K1Z5

    RNA

    1. XR_005488951.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5QE80.1 GenPept UniProtKB/Swiss-Prot:Q5QE80

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials