Slc25a47 solute carrier family 25, member 47 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a47provided by RGD
Official Full Name: solute carrier family 25, member 47provided by RGD
Primary source: RGD:1303247
See related: EnsemblRapid:ENSRNOG00000003020 AllianceGenome:RGD:1303247
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hdmcp; Slc24a47
Summary: Predicted to enable NAD transmembrane transporter activity and acetyl-CoA transmembrane transporter activity. Predicted to be involved in NAD transmembrane transport and acetyl-CoA transport. Predicted to be located in mitochondrial inner membrane and mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human SLC25A47 (solute carrier family 25 member 47). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 934.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (133531741..133537375)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (127767365..127773000)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (132762306..132767940)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HDMCP might function through promoting ATP depletion and decreasing H(2)O(2) production.
Title: HDMCP uncouples yeast mitochondrial respiration and alleviates steatosis in L02 and hepG2 cells by decreasing ATP and H2O2 levels: a novel mechanism for NAFLD.
hepatocellular carcinoma down-regulated mitochondrial carrier protein is a novel liver-specific uncoupling protein
Title: Cloning and identification of hepatocellular carcinoma down-regulated mitochondrial carrier protein, a novel liver-specific uncoupling protein.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables NAD transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables acetyl-CoA transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acetyl-CoA transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in NAD transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in acetyl-CoA transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: solute carrier family 25 member 47

Names: hepatocellular carcinoma down-regulated mitochondrial carrier homolog; mitochondrial NAD(+) transporter SLC25A47; mitochondrial hepatocellular carcinoma-downregulated carrier protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.