Sema7a semaphorin 7A (John Milton Hagen blood group) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sema7aprovided by RGD
Official Full Name: semaphorin 7A (John Milton Hagen blood group)provided by RGD
Primary source: RGD:1305192
See related: EnsemblRapid:ENSRNOG00000007687 AllianceGenome:RGD:1305192
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of macrophage cytokine production. Predicted to act upstream of or within nervous system development; positive regulation of axon extension; and positive regulation of protein phosphorylation. Predicted to be active in GABA-ergic synapse; external side of plasma membrane; and presynapse. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human SEMA7A (semaphorin 7A (JohnMiltonHagen blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 145.5), Thymus (RPKM 122.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (67244318..67267060)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (58348448..58370536)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (62723788..62746530)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sema7A, a brain immune regulator, regulates seizure activity in PTZ-kindled epileptic rats.
Title: Sema7A, a brain immune regulator, regulates seizure activity in PTZ-kindled epileptic rats.
SEMA7A promotes seawater induced lung edema via plexin C1 and stimulates seawater induced lung inflammation via beta1 integrin.
Title: Endothelial semaphorin 7A promotes seawater aspiration-induced acute lung injury through plexin C1 and β1 integrin.
This study shown that mrna of expression of semaphorin 7A after cell therapy in a mouse model of Parkinson's disease.
Title: Axon guidance molecule expression after cell therapy in a mouse model of Parkinson's disease.
Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence.
Title: Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence.
SEMA7A is critical in the development of lung inflammation and pulmonary edema in seawater aspiration-induced ALI, and may be a therapeutic target for this disease.
Title: Endothelial Semaphorin 7A promotes inflammation in seawater aspiration-induced acute lung injury.
These data identify Sema7A as a regulator of thalamocortical and local circuit development in layer 4 and provide a molecular handle that can be used to explore the coordinated generation of excitatory and inhibitory cortical circuits.
Title: Maturation of cortical circuits requires Semaphorin 7A.
Sema7A acts as a positive regulator for thalamocortical axon branching and/or pre-synaptic puncta formation
Title: The action of Semaphorin7A on thalamocortical axon branching.
After spinal cord injury, Sema7A-positive cells accumulate specifically in lesion areas resulting in significantly enhanced Sema7A expression at the injury site.
Title: Spinal cord injury induces differential expression of the profibrotic semaphorin 7A in the developing and mature glial scar.
Sema7A and plexinC1 expression patterns are consistent with these proteins serving both cooperative and separate functions during neural development
Title: Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migration.

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General gene information

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Markers

MDB0432 (e-PCR)
- UniSTS:125019

BE105763 (e-PCR)
- UniSTS:245905

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemorepellent activity	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
NOT enables neuropilin binding	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon extension	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within olfactory lobe development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse maturation	ISO Inferred from Sequence Orthology more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: semaphorin-7A

Names: sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A; semaphorin 7A, GPI membrane anchor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108153.1 → NP_001101623.1 semaphorin-7A precursor

See identical proteins and their annotated locations for NP_001101623.1

Status: PROVISIONAL

Source sequence(s)

CH473975

UniProtKB/TrEMBL

A6J4Y5, D3ZQP6

Related

ENSRNOP00000010620.5, ENSRNOT00000010620.7

Conserved Domains (3) summary

cd11243
Location:70 → 489

Sema_7A; The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)

pfam01437
Location:491 → 520

PSI; Plexin repeat

cl11960
Location:549 → 622

Ig; Immunoglobulin domain