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    Adcy7 adenylate cyclase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adcy7provided by RGD
    Official Full Name
    adenylate cyclase 7provided by RGD
    Primary source
    RGD:619966
    See related
    EnsemblRapid:ENSRNOG00000014776 AllianceGenome:RGD:619966
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables adenylate cyclase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and maternal process involved in female pregnancy. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ADCY7 (adenylate cyclase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 190.6), Lung (RPKM 141.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adcy7 in Genome Data Viewer
    Location:
    19p11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (34913154..34972366, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (18740875..18798924, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (19702307..19762973, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483621 Neighboring gene uncharacterized LOC120098503 Neighboring gene bromodomain containing 7 Neighboring gene uncharacterized LOC134483299 Neighboring gene terminal nucleotidyltransferase 4B Neighboring gene HEAT repeat containing 3 Neighboring gene uncharacterized LOC134483300

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Changes in the expression of adenylyl cyclases in the rat uterus during the course of pregnancy. Suzuki Y, et al. Biol Reprod, 1997 Oct. PMID 9314580
    2. Adenylyl cyclase isoforms in the vestibular periphery of the rat. Wackym PA, et al. Brain Res, 2000 Mar 24. PMID 10719090
    3. CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion. Alhaidan Y, et al. Front Endocrinol (Lausanne), 2021. PMID 34177802, Free PMC Article
    4. Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice. Duan B, et al. J Immunol, 2010 Jul 1. PMID 20505140, Free PMC Article
    5. Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons. Fan P, et al. Mol Pharmacol, 2009 Sep. PMID 19549762, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion.
      Title: CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to ethanol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lithium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maternal process involved in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenylate cyclase type 7
    Names
    adenylyl cyclase 7
    NP_445848.1
    XP_017456870.1
    XP_017456871.1
    XP_017456872.1
    XP_017456873.1
    XP_017456877.1
    XP_017456879.1
    XP_017456880.1
    XP_017456881.1
    XP_017456882.1
    XP_063134393.1
    XP_063134394.1
    XP_063134396.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053396.1 → NP_445848.1  adenylate cyclase type 7

      See identical proteins and their annotated locations for NP_445848.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6KDA2, F1LQT1
      Related
      ENSRNOP00000020700.5, ENSRNOT00000020700.7
      Conserved Domains (3) summary
      pfam00211
      Location:891 → 1087
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:21 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      34913154..34972366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601393.3 → XP_017456882.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      A6KDA2, F1LQT1
      Conserved Domains (3) summary
      pfam00211
      Location:891 → 1087
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:21 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    2. XM_017601388.3 → XP_017456877.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      A6KDA2, F1LQT1
      Conserved Domains (3) summary
      pfam00211
      Location:891 → 1087
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:21 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    3. XM_063278323.1 → XP_063134393.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      A6KDA2, F1LQT1

    4. XM_017601391.3 → XP_017456880.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      A6KDA2, F1LQT1
      Conserved Domains (3) summary
      pfam00211
      Location:891 → 1087
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:21 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    5. XM_017601381.3 → XP_017456870.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      A6KDA2, F1LQT1
      Conserved Domains (3) summary
      pfam00211
      Location:891 → 1087
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:21 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    6. XM_017601382.3 → XP_017456871.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      A6KDA2, F1LQT1
      Conserved Domains (3) summary
      pfam00211
      Location:891 → 1087
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:21 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    7. XM_017601384.3 → XP_017456873.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      A6KDA2, F1LQT1
      Conserved Domains (3) summary
      pfam00211
      Location:891 → 1087
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:21 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    8. XM_017601383.3 → XP_017456872.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      A6KDA2, F1LQT1
      Conserved Domains (3) summary
      pfam00211
      Location:891 → 1087
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:21 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    9. XM_017601390.3 → XP_017456879.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      A6KDA2, F1LQT1
      Conserved Domains (3) summary
      pfam00211
      Location:891 → 1087
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:21 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    10. XM_017601392.3 → XP_017456881.1  adenylate cyclase type 7 isoform X1

      UniProtKB/TrEMBL
      A6KDA2, F1LQT1
      Conserved Domains (3) summary
      pfam00211
      Location:891 → 1087
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:21 → 251
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:487 → 593
      DUF1053; Domain of Unknown Function (DUF1053)

    11. XM_063278324.1 → XP_063134394.1  adenylate cyclase type 7 isoform X2

    12. XM_063278326.1 → XP_063134396.1  adenylate cyclase type 7 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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