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    Rab11fip5 RAB11 family interacting protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312502, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Rab11fip5provided by RGD
    Official Full Name
    RAB11 family interacting protein 5provided by RGD
    Primary source
    RGD:1592069
    See related
    EnsemblRapid:ENSRNOG00000056009 AllianceGenome:RGD:1592069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable gamma-tubulin binding activity. Predicted to be involved in several processes, including postsynaptic neurotransmitter receptor internalization; regulation of protein localization; and secretion by cell. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in Golgi apparatus; centriolar satellite; and mitochondrial outer membrane. Predicted to be active in cytoplasmic vesicle and mitochondrion. Orthologous to human RAB11FIP5 (RAB11 family interacting protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 148.8), Heart (RPKM 133.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab11fip5 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (119428766..119466277, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (117871301..117908819, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (117113067..117154495, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102324 Neighboring gene empty spiracles homeobox 1 Neighboring gene sideroflexin 5 Neighboring gene argininosuccinate synthase 1, pseudogene 2 Neighboring gene notochord homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The rab11 effector protein FIP1 regulates adiponectin trafficking and secretion. Carson BP, et al. PLoS One, 2013. PMID 24040321, Free PMC Article
    2. Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts. Oehlke O, et al. J Cell Physiol, 2011 Mar. PMID 20717956
    3. Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis. Sugawara K, et al. Genes Cells, 2009 Apr. PMID 19335615
    4. Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. Chen D, et al. J Biol Chem, 2001 Apr 20. PMID 11278501
    5. The phagosomal proteome in interferon-gamma-activated macrophages. Trost M, et al. Immunity, 2009 Jan 16. PMID 19144319

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of adiponectin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rab11 family-interacting protein 5
    Names
    RAB11 family interacting protein 5 (class I)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399548.1 → NP_001386477.1  rab11 family-interacting protein 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2K4A0, A6IAR5
      Related
      ENSRNOP00000072961.2, ENSRNOT00000091374.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      119428766..119466277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108722.2 → XP_038964650.1  rab11 family-interacting protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K1W1
      Related
      ENSRNOP00000072006.2, ENSRNOT00000086720.3
      Conserved Domains (2) summary
      pfam09457
      Location:1265 → 1311
      RBD-FIP; FIP domain
      cl14603
      Location:21 → 167
      C2; C2 domain

    2. XM_039108723.2 → XP_038964651.1  rab11 family-interacting protein 5 isoform X2

      Conserved Domains (2) summary
      pfam09457
      Location:1163 → 1209
      RBD-FIP; FIP domain
      cl14603
      Location:21 → 167
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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