Ahnak AHNAK nucleoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ahnakprovided by RGD
Official Full Name: AHNAK nucleoproteinprovided by RGD
Primary source: RGD:619779
See related: EnsemblRapid:ENSRNOG00000057569 AllianceGenome:RGD:619779
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: UV118; AHNAK 1; RGD1308572
Summary: Predicted to enable S100 protein binding activity; identical protein binding activity; and structural molecule activity conferring elasticity. Predicted to be involved in regulation of RNA splicing and regulation of voltage-gated calcium channel activity. Predicted to be located in several cellular components, including cell-cell contact zone; extracellular exosome; and sarcolemma. Predicted to be part of plasma membrane protein complex. Predicted to be active in costamere and nucleus. Used to study autoimmune disease. Orthologous to human AHNAK (AHNAK nucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 7148.3), Heart (RPKM 4500.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (215311289..215400010)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (205882225..205970934)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (225184883..225429638)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our results clearly show the implication of AHNAK in myelinating Schwann cell adhesion to laminin, probably via targeting of the dystroglycan-associated receptor complex
Title: The giant protein AHNAK involved in morphogenesis and laminin substrate adhesion of myelinating Schwann cells.
Results suggest that AHNAK expression is associated with cell types displaying tissue-protective barrier properties, and with neoangiogenesis, following spinal cord injury.
Title: Spinal cord injury-induced up-regulation of AHNAK, expressed in cells delineating cystic cavities, and associated with neoangiogenesis.
AHNAK has a role in modulating calcium current in rat cardiomyocyte
Title: Calcium current in rat cardiomyocytes is modulated by the carboxyl-terminal ahnak domain.
Ahnak has a critical role in cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation
Title: Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation.
The carboxyl-terminal ahnak domain exerts a stabilizing effect on muscle contractility via its interaction with actin of thin filaments.
Title: The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction.
a marker of an extensive form of calcium-induced exocytosis
Title: Regulated exocytosis: a novel, widely expressed system.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140140 (e-PCR)
- UniSTS:222219

D1Bda59 (e-PCR)
- UniSTS:239812

RH139557 (e-PCR)
- UniSTS:221642

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity conferring elasticity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISS Inferred from Sequence or Structural Similarity more info
is_active_in costamere	IBA Inferred from Biological aspect of Ancestor more info
located_in costamere	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of plasma membrane protein complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: neuroblast differentiation-associated protein AHNAK

Names: desmoyokin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398671.1 → NP_001385600.1 neuroblast differentiation-associated protein AHNAK isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2JUA5

Related

ENSRNOP00000102284.1, ENSRNOT00000130158.1

Conserved Domains (3) summary

COG2911
Location:2614 → 2920

TamB; Autotransporter translocation and assembly factor TamB [Intracellular trafficking, secretion, and vesicular transport]

pfam05109
Location:4578 → 4776

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl00117
Location:23 → 91

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
NM_001398672.1 → NP_001385601.1 neuroblast differentiation-associated protein AHNAK isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6HZY6

Related

ENSRNOP00000098820.1, ENSRNOT00000134873.1

Conserved Domains (1) summary

cl00117
Location:23 → 91

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

215311289..215400010

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017588769.3 → XP_017444258.1 neuroblast differentiation-associated protein AHNAK isoform X2

UniProtKB/TrEMBL

A0A8I5ZUE6, A6HZY5, A6HZY6

Related

ENSRNOP00000081127.2, ENSRNOT00000112370.2

Conserved Domains (1) summary

cl00117
Location:23 → 91

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
XM_063278638.1 → XP_063134708.1 neuroblast differentiation-associated protein AHNAK isoform X1

UniProtKB/TrEMBL

A6HZY6

RNA

XR_005492950.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001191951.1: Suppressed sequence

Description

NM_001191951.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.