Acvr1c activin A receptor type 1C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acvr1cprovided by RGD
Official Full Name: activin A receptor type 1Cprovided by RGD
Primary source: RGD:621789
See related: EnsemblRapid:ENSRNOG00000004828 AllianceGenome:RGD:621789
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Alk7; Alk-7; habrec1
Summary: Enables several functions, including ATP binding activity; BMP receptor binding activity; and activin binding activity. Involved in several processes, including brain development; response to aldosterone; and transforming growth factor beta receptor superfamily signaling pathway. Located in cell surface. Part of activin receptor complex. Biomarker of retinal degeneration. Orthologous to human ACVR1C (activin A receptor type 1C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 72.2), Brain (RPKM 64.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (63224322..63301252, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (42815490..42892423, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (44272859..44342501, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats.
Title: Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats.
ALK7 gene silencing has a protective effect on diabetes-induced aortic stiffness, insulin resistance and hyperlipidemia, thus implicating a new potential therapeutic approach to diabetic macrovascular stiffness.
Title: Silencing of activin receptor-like kinase 7 alleviates aortic stiffness in type 2 diabetic rats.
Data suggest that up-regulation of Nodal expression increases apoptosis of beta cells and is associated with increased Alk7 expression, activation of Smad3 signaling, and down-regulation of apoptosis regulatory proteins.
Title: Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells.
Regulation of nodal/activin receptor-like kinase 7 signaling pathway play a role in the control of ovarian follicular atresia.
Title: Role and regulation of nodal/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia.
ALK7 induces apoptosis through activation of the traditional TGF-beta pathway components
Title: Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells.
pancreatic beta cell apoptosis induced by ALK7 activation occurs via the activation of two distinct downstream pathways
Title: Activin receptor-like kinase 7 induces apoptosis of pancreatic beta cells and beta cell lines.

Submit: New GeneRIF Correction

General gene information

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Markers

BE118782 (e-PCR)
- UniSTS:248887

BF390693 (e-PCR)
- UniSTS:249524

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables BMP receptor activity	IEA Inferred from Electronic Annotation more info
enables BMP receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables SMAD binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables activin binding	IDA Inferred from Direct Assay more info	PubMed
enables activin binding	IDA Inferred from Direct Assay more info	PubMed
enables activin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables activin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables activin receptor activity	ISO Inferred from Sequence Orthology more info
enables activin receptor activity, type I	IBA Inferred from Biological aspect of Ancestor more info
enables activin receptor activity, type I	IDA Inferred from Direct Assay more info	PubMed
enables activin receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables activin receptor activity, type I	ISO Inferred from Sequence Orthology more info
enables activin receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables growth factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IC Inferred by Curator more info	PubMed
enables nodal binding	IEA Inferred from Electronic Annotation more info
enables nodal binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transforming growth factor beta receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type III	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in SMAD protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic nuclear changes	IEA Inferred from Electronic Annotation more info
involved_in apoptotic nuclear changes	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
NOT acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
NOT acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid storage	ISO Inferred from Sequence Orthology more info
involved_in midbrain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of chorionic trophoblast cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chorionic trophoblast cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of trophoblast cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of trophoblast cell migration	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nodal signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in nodal signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IC Inferred by Curator more info	PubMed
involved_in regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to aldosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to dietary excess	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to glucose	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in transforming growth factor beta receptor complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in trophectodermal cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trophectodermal cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of activin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of activin receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of activin receptor complex	IEA Inferred from Electronic Annotation more info
part_of activin receptor complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: activin receptor type-1C

Names: ACTR-IC; TGF-beta type 1 receptor; activin A receptor, type IC; activin receptor type IC; activin receptor-like kinase 7

NP_620790.2

EC 2.7.11.30

XP_038960174.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139090.2 → NP_620790.2 activin receptor type-1C precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P70539, P70603

UniProtKB/TrEMBL

A6JF56, F1LQM3

Related

ENSRNOP00000056047.3, ENSRNOT00000059280.6

Conserved Domains (3) summary

cd14143
Location:199 → 486

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:33 → 95

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:166 → 193

TGF_beta_GS; Transforming growth factor beta type I GS-motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

63224322..63301252 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104246.2 → XP_038960174.1 activin receptor type-1C isoform X1

UniProtKB/Swiss-Prot

P70539, P70603

Conserved Domains (3) summary

cd14143
Location:172 → 459

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:33 → 95

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:139 → 166

TGF_beta_GS; Transforming growth factor beta type I GS-motif