Hgsnat heparan-alpha-glucosaminide N-acetyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hgsnatprovided by RGD
Full Name: heparan-alpha-glucosaminide N-acetyltransferaseprovided by RGD
Primary source: RGD:1560755
See related: EnsemblRapid:ENSRNOG00000069796 AllianceGenome:RGD:1560755
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560755
Summary: Predicted to enable heparan-alpha-glucosaminide N-acetyltransferase activity. Predicted to be involved in heparan sulfate proteoglycan catabolic process; lysosomal transport; and protein complex oligomerization. Predicted to be active in lysosomal lumen and lysosomal membrane. Human ortholog(s) of this gene implicated in mucopolysaccharidosis type IIIC and retinitis pigmentosa 73. Orthologous to human HGSNAT (heparan-alpha-glucosaminide N-acetyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 116.2), Lung (RPKM 109.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.4

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (72807967..72840180)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (66105233..66137444)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (70876557..70909443)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH141580 (e-PCR)
- UniSTS:223574

BF392550 (e-PCR)
- UniSTS:243543

AW529878 (e-PCR)
- UniSTS:261302

RH130939 (e-PCR)
- UniSTS:214223

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables heparan-alpha-glucosaminide N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in heparan sulfate proteoglycan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lysosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysosomal transport	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in lysosomal lumen	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heparan-alpha-glucosaminide N-acetyltransferase

Names: RGD1560755 protein-like

NP_001389399.1

EC 2.3.1.78

XP_056840862.1

EC 2.3.1.78

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.