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    Coa4 cytochrome c oxidase assembly factor 4 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Coa4provided by RGD
    Official Full Name
    cytochrome c oxidase assembly factor 4 homologprovided by RGD
    Primary source
    RGD:1562228
    See related
    EnsemblRapid:ENSRNOG00000077991 AllianceGenome:RGD:1562228
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Chchd8; RGD1562228
    Summary
    Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial intermembrane space. Orthologous to human COA4 (cytochrome c oxidase assembly factor 4 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 80.4), Adrenal (RPKM 78.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Coa4 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164294312..164297571)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154882199..154885445)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165549319..165552573)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691200 Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene uncharacterized LOC120099893 Neighboring gene uncharacterized LOC120099894 Neighboring gene mitochondrial ribosomal protein L48 Neighboring gene small nucleolar RNA SNORA4 Neighboring gene RAB6A, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells. Fischer M, et al. Mol Biol Cell, 2013 Jul. PMID 23676665, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188692

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil-helix-coiled-coil-helix domain-containing protein 8
    Names
    coiled-coil-helix-coiled-coil-helix domain containing 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127655.1 → NP_001121127.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 8

      See identical proteins and their annotated locations for NP_001121127.1

      Status: PROVISIONAL

      Source sequence(s)
      BC159412
      UniProtKB/TrEMBL
      A0A8I6GLA4, B0K013
      Related
      ENSRNOP00000111648.1, ENSRNOT00000142826.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      164294312..164297571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229782.5 → XP_006229844.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 8 isoform X1

    2. XM_006229783.5 → XP_006229845.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006229845.1

      UniProtKB/TrEMBL
      A0A8I6GLA4, B0K013
    Nucleotide Protein Strain
    Heading Accession and Version

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