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    Stx11 syntaxin 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292483, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Stx11provided by RGD
    Official Full Name
    syntaxin 11provided by RGD
    Primary source
    RGD:1304744
    See related
    EnsemblRapid:ENSRNOG00000014902 AllianceGenome:RGD:1304744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; synaptic vesicle fusion to presynaptic active zone membrane; and vesicle docking. Predicted to act upstream of or within cellular response to type II interferon and leukocyte degranulation. Predicted to be located in phagocytic vesicle. Predicted to be part of SNARE complex. Predicted to be active in endomembrane system and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 4. Orthologous to human STX11 (syntaxin 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 72.6), Spleen (RPKM 68.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stx11 in Genome Data Viewer
    Location:
    1p13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (9111216..9140227, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (7293427..7320060, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (7039160..7064870, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene utrophin Neighboring gene uncharacterized LOC134482577 Neighboring gene uncharacterized LOC134482578 Neighboring gene transfer RNA leucine (anticodon UAA) 1 Neighboring gene uncharacterized LOC120098780 Neighboring gene uncharacterized LOC120098781 Neighboring gene uncharacterized LOC134484945 Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation. D'Orlando O, et al. Eur J Immunol, 2013 Jan. PMID 23042080, Free PMC Article
    2. Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease. Kögl T, et al. Blood, 2013 Jan 24. PMID 23190531
    3. The phagosomal proteome in interferon-gamma-activated macrophages. Trost M, et al. Immunity, 2009 Jan 16. PMID 19144319
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC116325

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cytotoxic T cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within natural killer cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neutrophil degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025638.3 → NP_001020809.2  syntaxin-11

      See identical proteins and their annotated locations for NP_001020809.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K516, A6JP51
      Related
      ENSRNOP00000108874.1, ENSRNOT00000124313.1
      Conserved Domains (3) summary
      cd00179
      Location:41 → 193
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15878
      Location:203 → 265
      SNARE_syntaxin11; SNARE motif of syntaxin 11
      pfam00804
      Location:41 → 238
      Syntaxin; Syntaxin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      9111216..9140227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008758601.3 → XP_008756823.1  syntaxin-11 isoform X1

      See identical proteins and their annotated locations for XP_008756823.1

      UniProtKB/TrEMBL
      A0A0G2K516, A6JP51
      Related
      ENSRNOP00000111679.1, ENSRNOT00000163095.1
      Conserved Domains (3) summary
      cd00179
      Location:41 → 193
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15878
      Location:203 → 265
      SNARE_syntaxin11; SNARE motif of syntaxin 11
      pfam00804
      Location:41 → 238
      Syntaxin; Syntaxin
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials