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    Klk1c6 kallikrein 1-related peptidase C6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 408242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klk1c6provided by RGD
    Official Full Name
    kallikrein 1-related peptidase C6provided by RGD
    Primary source
    RGD:1303220
    See related
    EnsemblRapid:ENSRNOG00000068628 AllianceGenome:RGD:1303220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gk6; Gk11; Klk6; rGK-6
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 14.2) See more
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    Genomic context

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    See Klk1c6 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (103604150..103612366, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94467626..94475842, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (99947714..99964824, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kallikrein 1-related peptidase C4 Neighboring gene kallikrein-2-like Neighboring gene kallikrein related-peptidase 5 like, pseudogene 1 Neighboring gene kallikrein 1-related peptidase C2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evolution of the rat kallikrein gene family: gene conversion leads to functional diversity. Wines DR, et al. J Mol Evol, 1991 Jun. PMID 1908019
    2. Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen. Olsson AY, et al. Genomics, 2004 Jul. PMID 15203212
    3. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kallikrein 1-related peptidase C6
    Names
    glandular kallikrein 11
    glandular kallikrein Klk1c6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395125.1 → NP_001382054.1  kallikrein 1-related peptidase C6 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A8T7, A6JAL0
      Related
      ENSRNOP00000088798.2, ENSRNOT00000118250.2
      Conserved Domains (1) summary
      cd00190
      Location:25 → 254
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      103604150..103612366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270262.1 → XP_063126332.1  kallikrein 1-related peptidase C6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A8T7, Q6IE61

    2. XM_039086599.1 → XP_038942527.1  kallikrein 1-related peptidase C6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8T7
      Conserved Domains (1) summary
      smart00020
      Location:24 → 209
      Tryp_SPc; Trypsin-like serine protease

    3. XM_039086587.1 → XP_038942515.1  kallikrein 1-related peptidase C6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8T7
      Conserved Domains (1) summary
      cd00190
      Location:25 → 257
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. XM_063270266.1 → XP_063126336.1  kallikrein 1-related peptidase C6 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001003977.1: Suppressed sequence

      Description
      NM_001003977.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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