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    Spag11b sperm associated antigen 11b [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362580, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Spag11bprovided by RGD
    Official Full Name
    sperm associated antigen 11bprovided by RGD
    Primary source
    RGD:1562239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spag11; Spag11c; Spag11bl
    Expression
    Biased expression in Kidney (RPKM 11.5) and Testes (RPKM 7.8) See more
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    Genomic context

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    See Spag11b in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (77400193..77402752, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (70697810..70700336, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (75145234..75148750)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482415 Neighboring gene defensin beta 14 Neighboring gene sperm associated antigen 11A Neighboring gene defensin beta 34 Neighboring gene defensin beta 105B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dynamic changes in the spatio-temporal expression of the β-defensin SPAG11C in the developing rat epididymis and its regulation by androgens. Ribeiro CM, et al. Mol Cell Endocrinol, 2015 Mar 15. PMID 25657045
    2. Antimicrobial actions of human and macaque sperm associated antigen (SPAG) 11 isoforms: influence of the N-terminal peptide. Yenugu S, et al. Mol Cell Biochem, 2006 Mar. PMID 16411022
    3. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Patil AA, et al. Physiol Genomics, 2005 Sep 21. PMID 16033865
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results from the spatio-temporal expression, cellular distribution showed that SPAG11C may play a role in epididymal development and/or sperm function.
      Title: Dynamic changes in the spatio-temporal expression of the β-defensin SPAG11C in the developing rat epididymis and its regulation by androgens.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    sperm-associated antigen 11B; sperm associated antigen 11b-like
    Names
    sperm associated antigen 11C
    sperm associated antigen 11C-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037852.1 → NP_001032941.1  sperm-associated antigen 11B isoform 1 precursor

      See identical proteins and their annotated locations for NP_001032941.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ012093
      UniProtKB/TrEMBL
      D3ZML6, F7F947, Q30KI9

    2. NM_001304424.2 → NP_001291353.2  sperm associated antigen 11b-like precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      F7F947, Q30KJ0
      Conserved Domains (1) summary
      pfam05324
      Location:5 → 72
      Sperm_Ag_HE2; Sperm antigen HE2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      77400193..77402752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094089.2 → XP_038950017.1  sperm associated antigen 11b-like isoform X1

      Conserved Domains (1) summary
      pfam05324
      Location:111 → 162
      Sperm_Ag_HE2; Sperm antigen HE2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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