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    Prss54 serine protease 54 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prss54provided by RGD
    Official Full Name
    serine protease 54provided by RGD
    Primary source
    RGD:1307877
    See related
    EnsemblRapid:ENSRNOG00000023092 AllianceGenome:RGD:1307877
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Klkbl4; RGD1307877
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Orthologous to human PRSS54 (serine protease 54). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 165.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prss54 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9486059..9502900)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9479995..9496838)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (9895052..9911965)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene gem (nuclear organelle) associated protein 8, pseudogene 10 Neighboring gene GINS complex subunit 3 Neighboring gene uncharacterized LOC120098510 Neighboring gene coiled-coil domain containing 113 Neighboring gene casein kinase 2 alpha 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inactive serine protease 54
    Names
    plasma kallikrein-like protein 4
    protease, serine, 54

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013888.1 → NP_001013910.1  inactive serine protease 54 precursor

      See identical proteins and their annotated locations for NP_001013910.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079217
      UniProtKB/Swiss-Prot
      Q6AY28
      UniProtKB/TrEMBL
      A0A8I6AE32
      Related
      ENSRNOP00000103453.1, ENSRNOT00000147885.1
      Conserved Domains (1) summary
      cl21584
      Location:42 → 253
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      9486059..9502900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097553.1 → XP_038953481.1  inactive serine protease 54 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AE32
      Related
      ENSRNOP00000036855.5, ENSRNOT00000033953.6
      Conserved Domains (1) summary
      cl21584
      Location:42 → 255
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. XM_006255073.4 → XP_006255135.1  inactive serine protease 54 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AE32
      Conserved Domains (2) summary
      smart00020
      Location:42 → 244
      Tryp_SPc; Trypsin-like serine protease
      cl21584
      Location:42 → 244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. XM_039097556.1 → XP_038953484.1  inactive serine protease 54 isoform X6

      Conserved Domains (1) summary
      cl21584
      Location:42 → 159
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. XM_039097555.2 → XP_038953483.1  inactive serine protease 54 isoform X5

      Conserved Domains (1) summary
      cl21584
      Location:42 → 159
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    5. XM_039097557.2 → XP_038953485.1  inactive serine protease 54 isoform X7

      Conserved Domains (1) summary
      cl21584
      Location:42 → 159
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    6. XM_063277849.1 → XP_063133919.1  inactive serine protease 54 isoform X3

    7. XM_039097554.2 → XP_038953482.1  inactive serine protease 54 isoform X4

      UniProtKB/TrEMBL
      A6JY02
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY28.1 GenPept UniProtKB/Swiss-Prot:Q6AY28

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