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    Bdp1 BDP1 general transcription factor IIIB subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294687, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Bdp1provided by RGD
    Official Full Name
    BDP1 general transcription factor IIIB subunitprovided by RGD
    Primary source
    RGD:1308512
    See related
    EnsemblRapid:ENSRNOG00000017864 AllianceGenome:RGD:1308512
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable TFIIIC-class transcription factor complex binding activity. Predicted to be involved in RNA polymerase III preinitiation complex assembly. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor TFIIIB complex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 112. Orthologous to human BDP1 (BDP1 general transcription factor IIIB subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 132.1), Spleen (RPKM 102.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bdp1 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (33112518..33204270, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (31378407..31470140, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (30248458..30340211, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene CART prepropeptide Neighboring gene methylcrotonyl-CoA carboxylase subunit 2 Neighboring gene uncharacterized LOC120100687 Neighboring gene small EDRK-rich factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries. Vannini A. Biochim Biophys Acta, 2013 Mar-Apr. PMID 23031840
    2. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, et al. Cell Cycle, 2010 Sep 15. PMID 20890107, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables TFIIIC-class transcription factor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase III preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIIB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor TFIIIB component B'' homolog
    Names
    B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199195.2 → NP_001186124.1  transcription factor TFIIIB component B'' homolog isoform 2

      See identical proteins and their annotated locations for NP_001186124.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      B2RZ11
      Conserved Domains (1) summary
      pfam15087
      Location:60 → 164
      DUF4551; Protein of unknown function (DUF4551)

    2. NM_001402161.1 → NP_001389090.1  transcription factor TFIIIB component B'' homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      33112518..33204270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281495.1 → XP_063137565.1  transcription factor TFIIIB component B'' homolog isoform X1

      UniProtKB/TrEMBL
      D3ZDI4
      Related
      ENSRNOP00000024023.7, ENSRNOT00000024023.9

    2. XM_063281496.1 → XP_063137566.1  transcription factor TFIIIB component B'' homolog isoform X2

      Related
      ENSRNOP00000099095.1, ENSRNOT00000130376.1

    3. XM_063281497.1 → XP_063137567.1  transcription factor TFIIIB component B'' homolog isoform X3

    4. XM_063281498.1 → XP_063137568.1  transcription factor TFIIIB component B'' homolog isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106403.1: Suppressed sequence

      Description
      NM_001106403.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: BDP1 (GeneID:55814).
    Nucleotide Protein Strain
    Heading Accession and Version

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